Evidence map›Paper›PMID 41927530›Full record

ArticleNature communications2026

Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice.

Ken Matoba, Eisuke Dohi, Phoebe A Garcia, Jose Francis-Oliveira, Mirmohammadali Mirramezanializamini, Inssaf Berkiks, Frida Anguiano, Jana H Badrani, Oluwaseun Fatoba, Eric Y Choi and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Ken Matoba *Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Eisuke Dohi *Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-5365-4900
Phoebe A Garcia *Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0009-0003-2790-769X
Jose Francis-Oliveira *Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-1539-4618
Mirmohammadali MirramezanializaminiDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Inssaf BerkiksDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Frida AnguianoDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Jana H BadraniDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0001-6479-7969
Oluwaseun FatobaDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Eric Y ChoiDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-0023-6844
Julia SeeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Md Sorwer Alam ParvezDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-9726-1009
Takahiro KochiDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Norimichi ItoDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Rei MitaniDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Indigo V L RoseDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-0491-1269
Takashi ImaiDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
David K CrossmanDepartment of Genetics, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-0981-169X
Mikhail V PletnikovDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kenneth W WitwerDepartments of Molecular and Comparative Pathobiology and Neurology, and The Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Minae NiwaDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-8784-7815
Shin-Ichi KanoDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA. sikano@uabmc.edu.ORCID http://orcid.org/0000-0002-5171-3436

Funding

Impact of immune cell-derived exosomes and miRNAs on brain function and behaviorR01MH113645 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KANO, SHINICHI · 2018 to 2022
$2.2M
Role of glia and inflammation in altered synapse development in schizophreniaR00MH093458 · NIMH · JOHNS HOPKINS UNIVERSITY · PI KANO, SHINICHI · 2014 to 2016
$737k
Altered microRNA expression patterns in plasma extracellular vesicles from patients with first episode psychosisR21MH118492 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KANO, SHINICHI · 2019 to 2020
$408k
NIMH NIH HHS R00 MH093458NIMH NIH HHS R01 MH113645NIMH NIH HHS R21 MH118492U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH093458U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH113645U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH118492
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are cell-derived small membrane vesicles and circulate throughout the body, but the impact of circulating EVs on brain function and behavior remains elusive. Here, we report that wild-type (WT) mouse blood, particularly EVs, increases sociability in socially impaired immunodeficient Rag1

Indexed as

Extracellular VesiclesMicroRNAsSocial BehaviorAnimalsHomeodomain ProteinsMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsNerve Tissue ProteinsNeuronsPrefrontal CortexPyramidal CellsT-LymphocytesCNTNAP2 protein, mouseHomeodomain ProteinsMembrane ProteinsMicrofilament ProteinsMicroRNAsNerve Tissue ProteinsRAG-1 proteinShank3 protein, mouse

Identifiers

PMID41927530
PMCPMC13216276

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.