Evidence map›Paper›PMID 41927519›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Cross-sectional and longitudinal cognitive trajectories associated with dementia comorbidity clusters: Results from a 10-year follow-up real-world outpatient memory clinic in Brazil.

Fernando Jacob Lazzaretti, Lorenza Pabst Botton, Carlos Gustavo Lokschin, Andressa de Oliveira Felício, Julia Patatt, Jaderson Costa da Costa, Cristiano S Aguzzoli, Lucas Porcello Schilling

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Fernando Jacob LazzarettiSchool of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.ORCID 0009-0001-3212-3932
Lorenza Pabst BottonSchool of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Carlos Gustavo LokschinSchool of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Andressa de Oliveira FelícioSchool of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Julia PatattSchool of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Jaderson Costa da CostaSchool of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Cristiano S AguzzoliBrain Institute of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Lucas Porcello SchillingSchool of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Funding

Alzheimer's Association 24AACSF-1200375CAPES 88887.951210/2024-00CNPq 139910/2025-5The Global Brain Health Institute (GBHI), the Alzheimer's Association, and Alzheimer's Society (UK) GBHI ALZ UK-23-971089
6 · The paper itself

Abstract

introductionWe identified comorbidities associated with dementia and assessed the impact of comorbidity clusters on dementia patients' cognitive trajectories in a real-world Brazilian memory-clinic cohort.

methodsWe analyzed 500 individuals. Ridge-penalized logistic regressions assessed associations between comorbidities and dementia. Tetrachoric correlations and hierarchical clustering informed mixed-effects analyses of longitudinal trajectories.

resultsFazekas score ≥ 2 (odds ratio [OR] 2.48, 95% confidence interval [CI] 1.64-4.54), stroke (OR 2.15, 95% CI 1.23-3.23), alcohol abuse (OR 2.13, 95% CI 1.22-4.92), hearing loss (OR 1.99, 95% CI 1.06-3.94), visual loss (OR 1.94, 95% CI 1.04-4.01), and low education (OR 1.21, 95% CI 1.09-1.54) were associated with dementia cross-sectionally. Comorbidities formed four clusters: cerebrovascular, cardiometabolic, neurosensory, substance abuse. Higher cerebrovascular burden predicted a 158% faster rate of cognitive decline in individuals with dementia. DISCUSSION: Our findings show four dementia comorbidity clusters and identify cerebrovascular burden as a prognostic marker of faster cognitive decline.

Indexed as

DementiaAgedAged, 80 and overBrazilComorbidityCross-Sectional StudiesDisease ProgressionFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological Testscerebrovascular burdencomorbidity clustersdementialow‐ and middle‐income countriesreal world settings

Identifiers

PMID41927519
PMCPMC13052239

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.