Microglial reactivity predicts hippocampal, but not global, atrophy in cerebral small vessel disease.

Adriana Zainurin, Robin B Brown, Daniel J Tozer, Hugh S Markus

Abstract read

In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adriana ZainurinStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0009-0001-0019-2554

Robin B BrownStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Daniel J TozerStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Hugh S MarkusStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Funding

Medical Research Council experimental medicine MR/N026896/1National Institute for Health Research Clinical Research Networkthe Cambridge British Heart Foundation Centre of Research Excellence RE/24/130011The Cambridge University Hospitals Biomedical Research Centre NIHR203312Tun Taib Foundation scholarship

6 · The paper itself

Abstract

introductionCerebral small vessel disease (CSVD) is the most prevalent pathology underlying vascular dementia. Increased neuroinflammation and blood-brain barrier (BBB) permeability have been implicated in CSVD pathogenesis. We determined whether microglial reactivity and BBB permeability at baseline predicted whole-brain and hippocampal atrophy over one year, and cognitive impairment over four years.

methodsSeventy-seven patients with CSVD were recruited to this prospective study. Baseline microglial reactivity and BBB permeability were determined using

resultsGreater DISCUSSION: Our data suggests that microglial reactivity may play a role in hippocampal atrophy; potentially contributing to the increasingly recognized interaction between vascular and neurodegenerative pathology.

Indexed as

Cerebral Small Vessel DiseasesHippocampusMicrogliaAgedAtrophyBlood-Brain BarrierCognitive DysfunctionFemaleHumansIsoquinolinesMagnetic Resonance ImagingMalePositron-Emission TomographyProspective StudiesIsoquinolinesPK 11195blood‐brain barrierdementiaMRIneuroinflammationpositron emission tomographystrokevascular cognitive impairment

Identifiers

PMID41927515

DOI10.1002/alz.71336

PMCPMC13052279

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.