Evidence map›Paper›PMID 41927343›Full record

ArticleJournal for immunotherapy of cancer2026

Transforming growth factor β induced as a novel secreted immune checkpoint counterinhibiting human tumor-associated T cells.

Maria Manuela Rosado, Eleonora Timperi, Ombretta Melaiu, Sara Vitale, Sophie Bachy, Alessio Grimaldi, Mariachiara Corrado, Vanessa Mancini, Gabriela Leonti, Filippo Conti and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Maria Manuela RosadoDepartment of Research, Advanced Diagnostic and Technological Innovation Translational Research Functional Departmental Area, Regina Elena Institute, Roma, Italy.ORCID http://orcid.org/0000-0002-2779-3157
Eleonora TimperiUniversità Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Rome, Italy.
Ombretta MelaiuDepartment of Paediatric Haematology/Oncology and Cell and Gene Therapy, Bambino Gesu Pediatric Hospital IRCCS, Rome, Italy.
Sara VitaleIstituto Superiore di Sanità, Rome, Italy.
Sophie BachyStromaCare Co, Lyon, France.
Alessio GrimaldiDepartment of Molecular Medicine, Sapienza University of Rome, Roma, Italy.
Mariachiara CorradoDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Vanessa ManciniDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Gabriela LeontiDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Filippo ContiDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Ilenia CammarataDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Ivana CelardoDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Stephanie KucykowiczInstitute of Immunity and Transplantation, Division of Infection and Immunity, UCL, London, England.
Gloryanne Aidoo-MicahInstitute of Immunity and Transplantation, Division of Infection and Immunity, UCL, London, England.
Paula GrageraDepartment of Paediatric Haematology/Oncology and Cell and Gene Therapy, Bambino Gesu Pediatric Hospital IRCCS, Rome, Italy.
Daniele AccapezzatoDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Maria Del BenDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Valentina D'OriaConfocal Microscopy Core Facility, Bambino Gesu Pediatric Hospital, Roma, Italy.
Cristiano De StefanisFlow Cytometry and Histology Core Facilities, Bambino Gesu Pediatric Hospital, Roma, Italy.
Laura ForcinaDAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.
Fabrizio FrattaroliDepartment of General and Specialistic Surgery, Sapienza University of Rome, Rome, Italy.
Andrea PicchettoDepartment of General and Specialistic Surgery, Sapienza University of Rome, Rome, Italy.
Massimo ChiarettiDepartment of General and Specialistic Surgery, Sapienza University of Rome, Rome, Italy.
Giancarlo D'AmbrosioDepartment of General and Specialistic Surgery, Sapienza University of Rome, Rome, Italy.
Giuseppe GianniniDepartment of Molecular Medicine, Sapienza University of Rome, Roma, Italy.
Francesca BelardinilliDepartment of Molecular Medicine, Sapienza University of Rome, Roma, Italy.
Andrea ScarinciHepato-Pancreato-Biliary Surgery Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Gian Luca GraziHepato-Pancreato-Biliary Surgery Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Antonio MusaròDAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.
Mala K MainiInstitute of Immunity and Transplantation, Division of Infection and Immunity, UCL, London, England.
Micol E FioriIstituto Superiore di Sanità, Rome, Italy.
Doriana FruciDepartment of Paediatric Haematology/Oncology and Cell and Gene Therapy, Bambino Gesu Pediatric Hospital IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0003-3388-7296
Anca HenninoCancer Research Centre Lyon (CRCL), Lyon, France.
Vincenzo BarnabaDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy vincenzo.barnaba@fondazione.uniroma1.it.ORCID http://orcid.org/0000-0001-7908-8049

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated the hypothesis that transforming growth factor β induced (TGFBI), an extracellular matrix protein secreted in the microenvironment of several tumors, can act as a secreted immune checkpoint (sIC) that contributes to the suppression of human antitumor T cell responses. METHODS AND

resultsSerum TGFBI concentrations, measured by ELISA, were significantly higher in patients with colorectal cancer (CRC) and hepatocellular carcinoma than in healthy individuals and associated with poor overall survival. Strikingly, multiparametric flow cytometry analyses revealed that TGFBI was abundantly expressed by tumor cells or monocytes, and by various lymphoid cell types-including CD4

conclusionsTaken together, our data demonstrate that TGFBI acts as a sIC counter-regulating T cell activation, differentiation, and effector function, which can be restored by TGFBI blockade, with broad implications for novel immunotherapy strategies in solid tumors.

Indexed as

Carcinoma, HepatocellularColorectal NeoplasmsLiver NeoplasmsTransforming Growth Factor betaCD8-Positive T-LymphocytesFemaleHumansLymphocyte ActivationMaleMiddle AgedTransforming Growth Factor betaColorectal CancerHepatocellular CarcinomaImmune Checkpoint InhibitorImmunosuppressionT-Lymphocytes

Identifiers

PMID41927343
PMCPMC13158596

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.