Evidence map›Paper›PMID 41927279›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026

Translation of Intraoperative Molecular Imaging for Clinical Use.

Lauren T Rosenblum, Arjun Pant, Catherine Yip, Gary Kohanbash, W Barry Edwards, Marcus M Malek

Abstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lauren T RosenblumDepartment of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
Arjun PantDepartment of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
Catherine YipDepartment of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
Gary KohanbashDepartment of Neurological Surgery, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania; and.
W Barry EdwardsDepartment of Chemistry, University of Missouri-Columbia, Columbia, Missouri.
Marcus M MalekDepartment of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania; marcus.malek@chp.edu.

Funding

Postdoctoral Research Training in Biotherapy of CancerT32CA113263 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Udai S Kammula · 2006 to 2026
$3.6M
Intraoperative dual-labeled molecular tracer to improve surgery on neuroblastomaR01CA277664 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gary Kohanbash, Marcus M. Malek · 2023 to 2026
$2.3M
Intraoperative Molecular Imaging of Metastatic Osteosarcoma with 111In-dinutuximab-IR800F32CA287961 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSENBLUM, LAUREN TAYLOR · 2024 to 2025
$120k
NCI NIH HHS F32 CA287961NCI NIH HHS R01 CA277664NCI NIH HHS T32 CA113263
6 · The paper itself

Abstract

Intraoperative molecular imaging (IMI) is an evolving tool that enables targeted real-time visualization and delineation of tissue during surgery. IMI tracers can be fluorescent, radioactive, or dual-labeled. Their integration into the intraoperative setting is supported by several clinical trials, which led to Food and Drug Administration approval for a variety of these agents. Fluorescent tracers enable excellent spatial visualization, whereas radiotracers enable deep tissue detection, and dual-labeled tracers provide both. Novel activatable tracers that leverage properties of the tumor microenvironment are also being developed. Advances in imaging devices now permit IMI usage across diverse platforms, including minimally invasive surgery. Despite the limitations of autofluorescence, false-positive signals, and heterogeneity, the use of IMI continues to broaden in oncologic and nononcologic applications, driven by demonstrated improvements in surgical outcomes. In this review, we highlight the translation of IMI through clinical trials and future directions in IMI-guided surgery.

Indexed as

Molecular ImagingSurgery, Computer-AssistedTranslational Research, BiomedicalAnimalsHumansIntraoperative Perioddual-labeled tracersfluorescence-guided surgeryIMI-guided surgeryintraoperative molecular imagingradioguided surgery

Identifiers

PMID41927279
PMCPMC13224909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.