Evidence map›Paper›PMID 41927057›Full record

ArticleBone & joint open2026

Optimal clinical management of tenosynovial giant cell tumours: a UK perspective.

TGCT UK Consortium, Sydney Stern, Robert Ashford, Will Aston, C R Chandrasekar, Sam Hackett, Nadina Hood, Vasilios Karavasilis, Robin L Jones, Ahmed Mahbubl and 8 more

Abstract read
In one paragraph

Article in Bone & joint open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

TGCT UK Consortium
Sydney SternTGCT Support, Wayne, New Jersey, USA.ORCID 0000-0002-1479-605X
Robert AshfordLeicester Orthopaedics, University Hospitals of Leicester NHS Trust & Leicester Cancer Research Centre, Leicester, UK.
Will AstonOrthopaedic Oncology, Royal National Orthopaedic Hospital, Stanmore, UK.
C R ChandrasekarLiverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Sam HackettSarcoma Specialist centre, Sarcoma, UK.
Nadina HoodTGCT Support, Edgware, UK.
Vasilios KaravasilisSarcoma Unit, University College London Hospital NHS Foundation Trust, London, UK.
Robin L JonesSarcoma Unit, Royal Marsden Hospital and Institute of Cancer Research, London, UK.
Ahmed MahbublSarcoma Unit, University College London Hospital NHS Foundation Trust, London, UK.
Guy MorrisRoyal Orthopaedic Hospital, Birmingham, UK.
Jonathan PereraOrthopaedic Oncology, Royal National Orthopaedic Hospital, Stanmore, UK.
Sarah PratapOxford Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Beatrice M SeddonSarcoma Unit, University College London Hospital NHS Foundation Trust, London, UK.
Daniel StarkSt James's Institute of Oncology, Leeds, UK.
Jonathan StevensonRoyal Orthopaedic Hospital, Birmingham, UK.
Elaine RichardsonThe Robert Jones and Agnes Hunt Orthopedic Hospital, Oswestry, UK.
Sara RothschildThe Life Raft Group, Wayne, New Jersey, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Tenosynovial giant cell tumour (TGCT) management is variable across the UK. Our aim was to examine these differences in clinical practice and develop consensus statements regarding the management of TGCTs. Methods: A three-stage modified Delphi technique was conducted with surgical, clinical, and medical oncology experts from across the UK. Key areas of controversy were identified in a virtual meeting on 23 January 2025. This was followed by an online questionnaire that was iteratively refined, and a virtual consensus meeting on 2 September 2025, to discuss topics where agreement had not yet been reached. Results: This consensus developed a definition for unresectable TGCT and criteria for patient referral from TGCT local management to multidisciplinary team (MDT) review with access to current appropriate treatment options and further defined unresectable TGCT. Diffuse, recurrent, and/or unresectable TGCT, or those requiring complex procedures should be reviewed through a centralized MDT case review at a sarcoma centre, given the complex multidisciplinary nature of TGCT management. Conclusion: The clarification of classification of localized and diffuse TGCTs, and the definition of unresectable TGCTs, as well as standardizing the criteria for referral to a sarcoma MDT, will facilitate the improved management of TGCTs across the UK and address regional resource challenges.

Identifiers

PMID41927057
PMCPMC13046436

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.