Evidence map›Paper›PMID 41926719›Full record

ArticleJCO clinical cancer informatics2026

Association Between Obesity and Sex-Related Survival Difference in Lung Cancer.

Alexey Ryzhenkov, Salma Rachidi, Valtteri Nieminen, Marianna Niemi, Mads Albrecht Andersen, Johanna Niklander, Juuso Paajanen, Pooja Bhatnagar, Andreas Bjerrum, Paula Kauppi and 11 more

Abstract read
In one paragraph

Article in JCO clinical cancer informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Alexey RyzhenkovDepartments of Oncology and Hematology, iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.ORCID 0009-0003-3307-3265
Salma RachidiDepartments of Oncology and Hematology, iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Valtteri NieminenDepartments of Oncology and Hematology, iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.ORCID 0000-0002-3550-0561
Marianna NiemiHUS IT Management, Helsinki University Hospital, Helsinki, Finland.
Mads Albrecht AndersenDepartment of Oncology, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0001-6231-5823
Johanna NiklanderHUS IT Management, Helsinki University Hospital, Helsinki, Finland.
Juuso PaajanenHeart and Lung Center, Pulmonary Department, Helsinki University Hospital, Helsinki, Finland.
Pooja BhatnagarLeeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.ORCID 0000-0002-0645-8026
Andreas BjerrumDepartment of Oncology, Copenhagen University Hospital, Copenhagen, Denmark.
Paula KauppiHeart and Lung Center, Pulmonary Department, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-1065-330X
Stelios TheophanousLeeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.
Wei Hai DengDivision of Cancer Medicine, Oslo University Hospital, Oslo, Norway.ORCID 0000-0001-8194-9303
Zarah Van SchoorDepartment of Medical Oncology, Antwerp University Hospital, Antwerp, Belgium.
Annelies VerbiestDepartment of Medical Oncology, Antwerp University Hospital, Antwerp, Belgium.ORCID 0000-0001-9024-863X
Åslaug HellandDivision of Cancer Medicine, Oslo University Hospital, Oslo, Norway.
Johanna SanojaDepartments of Oncology and Hematology, iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.ORCID 0009-0004-7727-4111
Annelies JanssensMIPRO, University of Antwerp, Antwerp, Belgium.
Aija KnuuttilaDepartments of Oncology and Hematology, iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Ilkka IlonenDepartments of Oncology and Hematology, iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.ORCID 0000-0002-8149-3550
Eric FeyDepartments of Oncology and Hematology, iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.ORCID 0009-0005-7847-7479
Kimmo PorkkaDepartments of Oncology and Hematology, iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSurvival discrepancy between male and female patients in lung cancer is a well-known, but still poorly understood phenomenon. Previous studies have used different patient cohorts and clinical covariates and have not included obesity, which is associated with longer lung cancer survival. We evaluated the relationship between survival, obesity, sex and other covariates using comprehensive, harmonized patient cohorts and a federated analysis approach. MATERIALS AND

methodsInitial analyses were done in a retrospective, real-world cohort of 7,327 patients with lung cancer diagnosed at the Helsinki University Hospital from 2015 to 2024. Patients were stratified by BMI, and univariate and multivariate analyses of survival were performed. External validation of univariate analyses was performed on data from four European university hospitals (n = 12,700).

resultsHigher BMI was associated with a smaller sex-related survival difference. In the normal BMI cohort (18.5-25 kg/m

conclusionHigher BMI was associated with reduced survival gap between sexes, emphasizing the value of comprehensive covariate reporting in future clinical trials and observational studies.

Indexed as

Lung NeoplasmsObesityAgedBody Mass IndexFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsSex Factors

Identifiers

PMID41926719
PMCPMC13064837

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.