Evidence map›Paper›PMID 41926668›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

CD28-Targeted Enzyme-Responsive Conformation-Switching Peptide Self-Assembly for Selective T-Cell Acute Lymphoblastic Leukemia (T-ALL) Therapy.

Jun Li, Ziyu Jia, Dekun Li, Zhi-Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang and 1 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jun LiState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, P. R. China.
Ziyu JiaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, P. R. China.
Dekun LiState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, P. R. China.
Zhi-Wen HuState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, P. R. China.ORCID https://orcid.org/0000-0002-2615-4900
Yinghao DingState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, P. R. China.ORCID https://orcid.org/0009-0000-7710-0155
Shengyi ZhangState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, P. R. China.
Shengkun TuoState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, P. R. China.
Zhimou YangState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, P. R. China.ORCID https://orcid.org/0000-0003-2967-6920
Huisheng FuHemodialysis Center, Department of Nephrology, Tianjin Medical University General Hospital, Tianjin, P. R. China.
Ling WangState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, P. R. China.
Man-Di WangState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, P. R. China.ORCID https://orcid.org/0009-0002-2464-839X

Funding

National Natural Science Foundation of China 32171325National Natural Science Foundation of China 32571549National Natural Science Foundation of China W2412122Tianjin Natural Science Foundation Project 23JCZDJC01020
6 · The paper itself

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy with limited targeted therapies. CD28, a costimulatory receptor aberrantly overexpressed on T-ALL cells, presents a promising underexplored therapeutic target. In this study, we developed an enzyme-responsive self-assembling peptide, SA

Indexed as

CD28 AntigensPeptidesPrecursor T-Cell Lymphoblastic Leukemia-LymphomaAnimalsCell Line, TumorHumansMiceSignal TransductionTumor MicroenvironmentCD28 AntigensPeptidesCD28 receptorconformation transformationenzyme‐instructed self‐assemblypeptide self‐assemblyT‐cell acute lymphoblastic leukemia

Identifiers

PMID41926668
PMCPMC13285142

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.