Self-Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication.

Zehui Xiao, Shaolong Qiu, Jiangli Cao, Jifeng Liu, Zhiyong Song, Ting Du, Xinjun Du

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zehui XiaoState Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, P. R. China.

Shaolong QiuState Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, P. R. China.

Jiangli CaoState Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, P. R. China.

Jifeng LiuState Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, P. R. China.

Zhiyong SongCollege of Chemistry, Huazhong Agricultural University, Wuhan, P. R. China.

Ting DuState Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, P. R. China.

Xinjun DuState Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, P. R. China.

Funding

China Postdoctoral Science Foundation 2024M762373China Postdoctoral Science Foundation Special Funding Program 2025T180807National Key R&D Program of China 2023YFF1103900National Natural Science Foundation of China 32472322Natural Science Foundation of Tianjin 25JCYBJC00860Tianjin Science and Technology Plan Project 25YDTPJC00710

6 · The paper itself

Abstract

Ferroptosis and cuproptosis, two emerging forms of metal-dependent cell death, show potential in combating multidrug-resistant bacterial infections. However, their effectiveness is constrained by insufficient intracellular iron/copper levels, unintended toxicity to healthy cells. Here, we developed a self-amplifying, targeted nanocomposite (ct@HMCF-Dex) based on hollow mesoporous copper-iron sulfide (HMCF), citric acid (ct), and dextran (Dex), which specifically triggers extracellular bacterial cuproptosis/ferroptosis, effectively treating MRSA lung infections and wound infections. Under the bacterial-infected microenvironment, ct@HMCF-Dex can release Cu

Indexed as

Anti-Bacterial AgentsCopperCuproptosisFerroptosisAnimalsCitric AcidHumansIronOxidation-ReductionOxidative StressAnti-Bacterial AgentsCitric AcidCopperIroncuproptosis/ferroptosis‐likeFenton/Fenton‐like reactionsoxidative stresspneumoniawound healing

Identifiers

PMID41926624

DOI10.1002/advs.75101

PMCPMC13285168

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.