Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Sebastian F SalatheDepartment of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.
Edziu FranczakDepartment of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.
Zane BusickDepartment of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.
Frederick B BoakyeDepartment of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.
Julie AllenDepartment of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.
Andrew LutkewitteInternal Medicine, Division of Endocrinology and Clinical Pharmacology and KU Diabetes Institute, University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0001-7271-246X
Heather WilkinsDepartment of Neurology, University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0003-4563-4544
John ThyfaultDepartment of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0001-7920-7466
B A KuglerDepartment of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0003-0822-7106
Funding
Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Alan Tackett · 2017 to 2026
$27.6M
Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
Divergence in Aerobic Capacity Drives Liver and Brain HealthR01DK121497 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI THYFAULT, JOHN P · 2019 to 2022
$2.2M
Multidisciplinary Research Training Program in Alzheimer's Disease and Related DisordersT32AG078114 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Sandra A Billinger, Eric Dennis Vidoni · 2022 to 2026
$1.2M
Translating Obesity, Metabolic Dysfunction and Comorbid Disease StatesT32DK128770 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI John P Thyfault, Douglas E Wright · 2022 to 2026
$806k
BLRD VA I01 BX002567HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 5T32DK128770HHS | NIH | National Institute on Aging (NIA) T32AG07811HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) R01DK121497NIA NIH HHS T32 AG078114NIDDK NIH HHS R01 DK121497NIDDK NIH HHS T32 DK128770NIGMS NIH HHS P20 GM121293NIGMS NIH HHS R24 GM137786U.S. Department of Veterans Affairs (VA) 1I01BX002567-05
6 · The paper itself
Abstract
Menopause is linked to cognitive decline and reduced brain metabolism, whereas estrogen (E2) therapy has been shown to mitigate these effects. Understanding the molecular mechanisms by which ovarian hormones and E2 influence neuroprotection is essential for developing strategies to maintain brain health in women. In this study, we examined how the loss of ovarian hormones, with or without E2 treatment, affects the brain proteome and mitochondrial energy production in aged female C57BL/6J mice (36-40 wk). The mice underwent sham or ovariectomy (OVX) surgery and were fed a high-fat diet for 10 wk; 6 wk after surgery, OVX mice received either sesame oil or E2 treatment for 4 wk. Proteomic analysis of brain homogenates revealed 4,992 proteins regulated by E2, with pathway analysis showing increased signaling proteins related to synaptogenesis. OVX reduced proteins involved in synaptic function, branched-chain amino acid and ketone metabolism, the tricarboxylic acid cycle, and oxidative phosphorylation (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Loss of ovarian function and estrogen therapy remodel the brain's synaptic and metabolic proteome. · full record | OpenQuestion