ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2026
Prevalence and Impact of Cardiovascular Comorbidities on Disease Outcomes in a Middle Eastern Chronic Lymphocytic Leukemia Population: A Retrospective Study at Kuwait Cancer Control Center.
Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesWe aimed to investigate the prevalence of comorbidities including diabetes mellitus (DM), hypertension, dyslipidemia, and cardiovascular disease in the Middle Eastern chronic lymphocytic leukemia (CLL) population and their correlation with disease outcome at the Kuwait Cancer Control Center (KCCC).
methodsWe performed a retrospective study of the CLL patients diagnosed in the KCCC between 2008 and 2021. The hazards ratio (HR) of death was calculated using Cox regression analysis. Statistical analysis was performed using SPSS (v27).
resultsA total of 316 patients had recorded comorbidities. The mean age at diagnosis was 60 years (SD + 13) with a male-to-female ratio of 3:1. Of these, 140 (44%) had hypertension, 132 (42%) had DM, and 32 (10%) had dyslipidemia. Nineteen CLL patients (6%) had vascular disease at diagnosis and 48 (15%) had a cardiac disease. The HR of death in patients with DM, hypertension, and dyslipidemia was 1.74 (1.04-2.89; p value 0.034), 1.14 (0.68-1.91; p value 0.628), and 1.91 (0.91-3.77; p value 0.063), respectively. The vascular disease and the cardiac disease were associated with HR of death of 3.48 (1.69-7.15; p value <0.001) and 1.39 (0.74-2.61; p value 0.312), respectively. In the multivariate analysis, vascular comorbidities remained as an independent predictor of death with an HR of 2.96 (1.41-6.21; p value = 0.004).
conclusionThe cardiovascular disease and associated risk factors are prevalent in the Kuwaiti CLL patients, and they are also associated with an unfavorable prognosis.
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