ArticleClinical ophthalmology (Auckland, N.Z.)2026
Association Between Serum Anti-Acetylcholine Receptor (AChR-Ab) Titers and Clinical Outcomes in Patients with Ocular-Onset Myasthenia Gravis: An Academic Retrospective Cohort Study.
Article in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Acetylcholine receptor antibodies (AChR-Ab) are established biomarkers in myasthenia gravis (MG). In ocular MG (OMG), their presence has been linked to disease severity, treatment response, and progression to generalized MG (GMG); however, the relevance of AChR-Ab titers or seropositivity to ocular manifestations remains uncertain. Objective and Method: We retrospectively reviewed OMG patients treated at Rajavithi Hospital (2009-2024). AChR-Ab titers were measured using enzyme-linked immunosorbent assay (ELISA). Clinical and demographic factors associated with AChR-Ab seropositivity (AChR-Ab Results: Among the 111 patients with OMG, 51 patients (45.9%) were AChR-Ab Conclusion: Serostatus of acetylcholine receptor antibodies may be useful for identifying MG patients at higher risk of generalization or thymoma, while antibody titers may provide complementary information, particularly in relation to thymoma, rather than serving as direct markers of disease severity or ocular manifestations.
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