Evidence map›Paper›PMID 41926443›Full record

ArticlePLOS global public health2026

Perceived benefits of community-based TB preventive treatment in children in Uganda: "When she sees other children getting the same medication, she will feel not alone."

Elijah Ronald Kakande, Jason Johnson-Peretz, Rachel Abbott, Bob Ssekyanzi, Maxim Twinomujuni, Fred Atwiine, Milliam Korukiiko, Hellen Nakato Atuhaire, Joan Nangendo, Gloria Nattabi and 9 more

Abstract read
In one paragraph

Article in PLOS global public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Elijah Ronald KakandeInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID https://orcid.org/0000-0001-9532-5710
Jason Johnson-PeretzDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, California, United States of America.ORCID https://orcid.org/0000-0001-9561-6366
Rachel AbbottDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, California, United States of America.
Bob SsekyanziInfectious Diseases Research Collaboration, Kampala, Uganda.
Maxim TwinomujuniInfectious Diseases Research Collaboration, Kampala, Uganda.
Fred AtwiineInfectious Diseases Research Collaboration, Kampala, Uganda.
Milliam KorukiikoInfectious Diseases Research Collaboration, Kampala, Uganda.
Hellen Nakato AtuhaireInfectious Diseases Research Collaboration, Kampala, Uganda.
Joan NangendoImplementation Science Program, School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda.
Gloria NattabiInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID https://orcid.org/0009-0002-3797-3052
Willington ArihoInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID https://orcid.org/0009-0006-2181-2085
Geoff LavoyInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID https://orcid.org/0009-0009-0123-147X
Gabriel ChamieDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, California, United States of America.
Laura B BalzerDivision of Biostatistics, University of California Berkeley, Berkeley, California, United States of America.
Diane V HavlirDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, California, United States of America.
Fred C SemitalaInfectious Diseases Research Collaboration, Kampala, Uganda.
Edwin CharleboisDepartment of Medicine, Center for AIDS Prevention Studies, Division of Prevention Science, University of California, San Francisco, San Francisco, California.ORCID https://orcid.org/0000-0001-7237-2119
Moses R KamyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Carina MarquezDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, California, United States of America.ORCID https://orcid.org/0000-0002-7622-6562

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis preventive treatment (TPT) uptake among children at risk for TB remains low in sub-Saharan Africa. Community-based TPT delivery is effective at increasing uptake and completion in children compared to clinic-based models, but implementation research is needed to inform scale-up in real-world settings. In this qualitative study, we assessed community and health care provider perspectives on the anticipated benefits and barriers of a community-based TPT differentiated delivery model comprising three components: (1) initial screening and TPT initiation at the nearest public health facility; (2) community health worker (CHW)-led TB education with community-based medication delivery; and (3) CHW-facilitated delivery in a Community Adherence Group (CAG). From 5 September to 12 October 2023, we conducted in-depth semi-structured interviews (N = 20) with a purposively selected sample of six public health care providers, four CHWs, and ten caregivers of children with latent TB infection. A six-person multi-regional research team translated and coded transcripts. Framework analysis was used to identify perceived benefits and barriers. Participants identified five main benefits: (1) comfort receiving care in the community due to familiarity with differentiated HIV care models and trust in CHWs; (2) peer support in CAGs promoting adherence and reducing stigma; (3) reduced transport costs; (4) improved efficiency through reduced waiting times and provider workload; and (5) enhanced CHW capacity to provide TB prevention services and increase community awareness. Perceived barriers included low community knowledge, need for a consistent drug supply, stigma, and inadequate CHW training. Caregivers, healthcare workers, and CHWs identified peer support, trust in CHWs, reduced transport costs, and increased efficiency as key benefits. Implementation efforts should address these barriers to optimize delivery in rural East Africa and similar settings. Integration of CAGs into community-based TPT models warrants further study.

Identifiers

PMID41926443
PMCPMC13046145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.