ArticleMolecular biology of the cell2026
Steady-state epithelial apical flatness is characterized by MLCK morphodynamics and asynchronous Ca
Article in Molecular biology of the cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The canonical simple epithelium is a flat sheet-like tissue of horizontally packed cells. While the basal surface is delineated by the basement membrane of extracellular matrix (ECM), little is known about how a flat apical surface is maintained, or if apical/basal dynamics are coordinated. The current study tests the role of the apical domain to define mechanisms involved in maintaining a flat apical geometry in an epithelium. When the basal geometry is modulated, Madin-Darby Canine Kidney (MDCK) cells adjust their morphology to maintain an overall apical flatness of the confluent layer. Pharmacological and transgenic disruption of non-muscle myosin ATPase and MLCK activity results in an uneven apical structure and overall loss of the flat geometry typical of a confluent epithelium. Surprisingly, transgenic experimentation showed that forces maintaining individual MDCK cell flatness are cell-autonomous. Finally, Ca
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