ReviewCurrent neuropharmacology2026
From Bench to Bedside: Understanding General Anesthetics' Impact on PTSD.
Review in Current neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-traumatic stress disorder (PTSD) is a multifaceted mental health disorder arising from exposure to traumatic events, characterized by persistent and distressing symptoms. Recent years have seen growing recognition of anesthesia's dual role in PTSD. While countless patients receive anesthetics during traumatic medical care, their long-term psychological impacts remain unclear, raising urgent clinical questions. This review provides an in-depth analysis of both clinical and animal studies examining the effects of commonly used inhaled and intravenous anesthetics, such as sevoflurane/isoflurane, benzodiazepines (BZDs), ketamine, propofol, and dexmedetomidine (Dex), on PTSD. These studies reveal a complex interplay between these anesthetic agents and PTSD, highlighting their potential to either alleviate or exacerbate symptoms depending on various factors such as dosage, timing, and individual susceptibility. Additionally, this review synthesizes the current understanding of the underlying neurobiological mechanisms through which these anesthetics affect fear memory and neuroplasticity, offering valuable insights into their potential applications and limitations in managing PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.