ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
Integrative bioinformatic and experimental analysis reveals prognostic and immunological roles of psychological stress-related genes in skin cutaneous melanoma.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSkin cutaneous melanoma (SKCM) represents the most aggressive type of skin cancer. Accumulating evidence underscores the critical involvement of chronic psychological stress and depressive states in cancer development. Genes linked to psychological stress pathways are known to regulate tumor dynamics and may serve as prognostic indicators. However, their precise implications for SKCM patient outcomes and the efficacy of immunotherapeutic interventions remain to be fully elucidated.
methodsPrognostically significant psychological stress-related genes (PSRGs) were first screened via univariate Cox regression in The Cancer Genome Atlas (TCGA) cohort. An optimal gene signature was then developed using least absolute shrinkage and selection operator regression, followed by multivariate Cox analysis. The prognostic accuracy of the signature was evaluated through Kaplan-Meier survival curves, area under the curve (AUC) values, and calibration plots. To uncover associated biological processes, pathway and immune infiltration analyses were performed comparing groups stratified by signature risk scores.
resultsFrom an initial panel of 374 PSRGs, 64 were significantly correlated with overall survival (OS). A 12-gene prognostic signature was ultimately constructed. The model demonstrated AUCs of 0.766 and 0.644 for 5-year OS prediction in the TCGA training set and the GSE65904 validation set, respectively. A lower signature score was associated with improved survival outcomes, an immunologically active tumor microenvironment enriched for CD8
conclusionThis study establishes a 12-gene signature based on PSRGs, which reliably forecasts clinical prognosis in SKCM. The signature captures features of an immune-activated microenvironment, indicating its dual utility for refining risk stratification and predicting benefit from immunotherapy.
Indexed as
Identifiers
41926057What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.