Evidence map›Paper›PMID 41926007›Full record

ArticleBioresources and bioprocessing2026

Chitosan-mediated nano-bioprocessing of Acacia seyal seed extract for enhanced antineoplastic, anti-Helicobacter pylori and antioxidant performance.

Aisha M H Al-Rajhi, Marwa Yousry A Mohamed, Areej Mothana, Abdulaziz Debaji, Magdah Ganash, Yahya Ali, Asmaa A Alharbi, Tarek M Abdelghany

Abstract read
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In one paragraph

Article in Bioresources and bioprocessing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aisha M H Al-RajhiDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia.
Marwa Yousry A MohamedDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), P.O.Box 90950,, Riyadh 11623,, Saudi Arabia.
Areej MothanaPharmacy Department, Jazan University Hospital, Jazan University, Jazan, Saudi Arabia.
Abdulaziz DebajiDepartment of Laboratories, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Magdah GanashDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Yahya AliDepartment of Biology, College of Science, Jazan University, P.O. Box 114, Jazan 45142,, Saudi Arabia.
Asmaa A AlharbiDepartment of Biology, College of Science, Jazan University, P.O. Box 114, Jazan 45142,, Saudi Arabia.
Tarek M AbdelghanyBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, 11725, Egypt. tabdelghany.201@azhar.edu.eg.ORCID http://orcid.org/0000-0001-6418-5890

Funding

Princess Nourah Bint Abdulrahman University (PNURSP2026R217
6 · The paper itself

Abstract

Acacia seyal is a medicinal plant rich in bioactive compounds known for their antimicrobial, antioxidant, and anticancer properties. Conventional plant extracts often suffer from poor stability and limited bioavailability, reducing their therapeutic effectiveness. The utilization of chitosan nanoparticles (CS-NPs) offers a promising strategy to enhance biological activity of plant extracts. Encapsulation of A. seyal seeds extract (ASSE) in CS-NPs (ASSE@CS-NPs) was the aim of the present investigation to compete Helicobacter pylori and HCT116 cancer cells. The phytochemical profile of ASSE revealed diverse phenolic acids and flavonoids via HPLC analysis. Methyl gallate was dominated (20.98 mg/g), followed by gallic acid, and catechin. FTIR analysis confirmed characteristic functional groups in ASSE and CS-NPs. Peak shifts and intensity variations in ASSE@CS-NPs indicated successful encapsulation through hydrogen bonding and electrostatic interactions. ASSE@CS-NPs showed the strongest anti-H. pylori effect with inhibition zone (23.7 mm) and lowest MIC/MBC (15.62 µg/mL). Compared to CS-NPs (20.7 mm, 31.25 µg/mL) and ASSE (19.7 mm, 31.25 µg/mL). ASSE@CS-NPs showed notable antioxidant activity, achieving 96% scavenging at 1000 µg/mL with IC

Indexed as

Acacia seyalChitosan nanoparticlesHCT116 cellsHelicobacter pyloriMethyl gallate

Identifiers

PMID41926007
PMCPMC13047003

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.