ArticleMolecular biology reports2026
circFKBP8(5S,6)-encoded protein modulates α-synuclein expression in SH-SY5Y cells.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundParkinson’s disease (PD) is the second most common neurodegenerative disease globally, characterized by the abnormal aggregation of α-synuclein. Recent studies suggest that circular RNAs (circRNAs), predominantly formed by back-splicing of pre-mRNAs, and the proteins they encode are implicated in neurodegenerative diseases; however, the specific role of circular RNA-encoded proteins in PD is understudied. This study investigated the expression and functional role of the circFKBP8(5S,6)-encoded protein (cFKBP8), translated from the circular RNA circFKBP8(5S,6), in a cellular model of PD. METHODS AND
resultsAn in vitro PD model was created by treating SH-SY5Y cells with 1-methyl-4-phenylpyridinium (MPP⁺). cFKBP8 expression was assessed using immunofluorescence staining and quantitative real-time polymerase chain reaction (RT-qPCR). An increase in cFKBP8 expression was found in MPP⁺-treated cells compared to untreated controls. Functional analyses using Western blot revealed that cFKBP8 overexpression significantly increased α-synuclein expression. In contrast, silencing cFKBP8 decreased α-synuclein levels in SH-SY5Y cells.
conclusionsThese results indicate that cFKBP8 expression is increased in a cellular model of PD and can influence α-synuclein expression in SH-SY5Y cells, thereby highlighting the role of circRNA-encoded proteins in α-synuclein biology, with potential implications for developing biomarkers and therapeutic strategies for PD.
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