ArticleMolecular biology reports2026
Genotypic and expression analysis of the insulin- like growth factor (IGF-1) gene across growth stages in indigenous sheep.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowth traits are critical determinants of productivity and profitability in sheep breeding programs. The Insulin-like growth factor-1 (IGF-1) gene plays a key role in regulating growth, metabolism, and carcass traits. The genetic analysis of IGF-1 genetic polymorphism, circulating hormone levels and age-specific gene expression at different growth stages in Muzaffarnagari sheep has not been previously reported. The present study was designed to analyze IGF-1 polymorphism, plasma IGF-1 concentration and gene expression pattern across different age groups in Muzaffarnagari sheep breed. METHODS AND
resultsGenotyping of IGF-1 gene was carried out using high resolution melting (HRM) analysis and revealed three genotypes in the population. The percent distribution of AA, AB and BB genotypes were 91.6%, 6.3% and 2.1%, respectively. The plasma IGF-1 concentration was measured by ELISA at various age groups such as 3 months, 9 months, and adults (> 18 months). The least squares means of plasma IGF1 concentration was 7.76, 9.63 and 12.69 ng/mL at 3, 9 months of age and adults, respectively, which was significantly higher (p < 0.05) in adults. Gene expression analysis was carried out using peripheral blood mononuclear cells (PBMCs), which provides a reliable source for assessing the endocrine-related transcriptional activity. The m-RNA expression pattern of IGF-1 at 3, 9 months and adult age groups had 1.867, 3.052 and 1.701-fold as compared to the control.
conclusionThe IGF plays a significant role in growth regulation during multiple development stages in sheep, however, it required to understand the role of IGF-1 at cellular level as well establish the association with production performance in-vivo. Overall, the present study provides novel insights into the genetic polymorphism, endocrine, and transcriptional regulation of IGF-1 gene in Muzaffarnagari sheep with implications for marker-assisted selection in growth-oriented breeding programs.
Indexed as
Identifiers
41925904What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.