ArticleJournal of neurology2026
Functional head impulse testing for detection and quantification of vestibular dysfunction in multiple sclerosis.
Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple sclerosis (MS) is the most prevalent cause of non-traumatic neurological disability in young adults. Vestibular dysfunction (VD) is frequently observed in MS patients and may considerably impair their daily activities. Early diagnosis of VD is pivotal for optimizing treatment.
methodsA total of 36 patients (29 females; mean age: 45.5 ± 10.6 years) with relapsing-remitting MS (RRMS) were enrolled. The presence of VD was investigated, and patients were identified as positive for VD (VD-RRMS; 19 patients; 18 females; mean age: 44.9 ± 11.4) and asymptomatic (A-RRMS; 17 patients; 11 females; mean age: 46.2 ± 9.9). VD was assessed using a Vestibular Symptoms Classification (VSC), assigning one point each for the presence of vertigo, postural instability, and nystagmus (0-3). The functional head impulse test (fHIT) was administered with rightward and leftward passive horizontal head rotation in all patients, and the test performance was quantified as the percentage of correctly identified Landolt C optotypes during head rotations. Lesion load was quantified via semiautomated lesion segmentation at Magnetic Resonance Imaging, extracting total lesion number/volume and regional lesion counts.
resultsANOVA indicated a significant main effect of VD factor on leftward and rightward fHIT performance, with a lower percentage of correct responses in the VD-RRMS group compared to A-RRMS group (p < 0.05). A negative correlation was identified between VSC and fHIT performance (p < 0.05). Finally, higher lesion burden predicted poorer fHIT performance, with total and periventricular lesion counts emerging as significant negative predictors.
conclusionsThe fHIT is a safe, noninvasive and rapid test to assess the VD presence and correlate the performance with the VSC in RRMS patients. The fHIT might be investigated longitudinally to monitor VD worsening and develop a more effective therapeutic strategy.
Indexed as
Identifiers
41925865What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.