ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026
Protectin DX reduces inflammatory pain initiated by superoxide anion in mice: targeting leukocyte recruitment, oxidative stress, cytokine production and TRPV1
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
OBJECTIVE AND
designThis study investigated the antinociceptive potential and mechanisms of Protectin DX (PDX) in a KO TREATMENT: Male mice received PDX (1, 3, or 10 ng) or vehicle (0.7% ethanol in sterile saline) intraperitoneally (i.p.), 1 h before KO
methodsUpon KO
resultsPDX reduced evoked and non-evoked pain, leukocyte recruitment, production of pro-inflammatory cytokines (TNF-α and IL-1β), and oxidative stress. PDX inhibited TRPV1 activity, resulting in inhibition of nociceptive neuron activation. PDX did not alter the plasma levels of ALT, AST, urea, and creatinine, or stomach myeloperoxidase activity. Also, PDX did not affect the basal mechanical and thermal sensitivity and motor activity.
conclusionPDX inhibits superoxide anion-triggered pain and inflammation, through anti-inflammatory, antioxidant, and neuronal component modulation mechanisms.
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