ArticlePsychopharmacology2026
Place preference in a female adolescent rat model of neuropathic pain: The effects of cannabidiol and oxycodone on cerebellum cell density.
Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationalePain reflects an integration of sensation, cognition, and affect, whereas chronic pain is associated with maladaptation. The cerebellum is increasingly recognised as a contributor to pain, especially towards affective-motivational facets, including relief-seeking from aversive experiences. Few have specifically investigated this, and much less in females, despite the notable prevalence of chronic pain in this population.
objectivesTo examine preference to seek cannabidiol- or oxycodone-analgesia, and cellular changes to the cerebellum in a female adolescent rat model of neuropathic pain.
methodsWe used a sciatic nerve chronic constriction injury (CCI) to model neuropathic pain in 6-week-old female rats and assessed thermal/mechanical nociception and anxiety-like behaviour. Preference for cannabidiol or oxycodone was quantified in a conditioned place preference paradigm. Immunostained and cleared cerebella were analysed for calbindin-positive Purkinje cells and parvalbumin-positive molecular layer interneurons within anterior (II–III, IV–V) and posterior (VI/Simplex, VII/Crus I) lobules.
resultsCCI evoked heat and cold allodynia, increased anxiety-like behaviour, and produced a place preference for cannabidiol and oxycodone. CCI resulted in minimal changes to calbindin-positive Purkinje cell or parvalbumin-positive interneuron density, however cannabidiol and oxycodone conditioning differentially modified cell density within the cerebellum of naïve and CCI animals.
conclusionsChronic neuropathic pain in female rats encourages seeking of cannabidiol and oxycodone, which may reflect ongoing affective disturbances. Cellular changes in the cerebellum were limited in this model of neuropathic pain, but unique cerebellar adaptations emerged following exposure to cannabidiol versus oxycodone. Further insight regarding cerebellar contributions to affective-motivational facets of chronic pain would be valuable.
Indexed as
Identifiers
41925821What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.