Evidence map›Paper›PMID 41925776›Full record

ArticleDigestive diseases and sciences2026

Coal Dust Nanoparticles Induce Colitis-Like Lesions in Rats via Gut Microbiota Dysbiosis and P53/SCO2/SLC7A11-Mediated Epithelial Ferroptosis.

Yazhen Zhang, Yuhan Ma, Cancan Jiang, Yao Liu, Yao Xu, Qiuxue Yang, Yuting Huang, Xinkuang Liu, Shuping Zhou, Yinci Zhang

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In one paragraph

Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yazhen Zhang *The First Hospital of Anhui University of Science and Technology, Huainan, 232000, Anhui Province, China.
Yuhan Ma *Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, 230032, China.
Cancan Jiang *The First Hospital of Anhui University of Science and Technology, Huainan, 232000, Anhui Province, China.
Yao LiuThe First Hospital of Anhui University of Science and Technology, Huainan, 232000, Anhui Province, China.
Yao XuThe First Hospital of Anhui University of Science and Technology, Huainan, 232000, Anhui Province, China.
Qiuxue YangThe First Hospital of Anhui University of Science and Technology, Huainan, 232000, Anhui Province, China.
Yuting HuangThe First Hospital of Anhui University of Science and Technology, Huainan, 232000, Anhui Province, China.
Xinkuang LiuThe First Hospital of Anhui University of Science and Technology, Huainan, 232000, Anhui Province, China.
Shuping ZhouThe First Hospital of Anhui University of Science and Technology, Huainan, 232000, Anhui Province, China.
Yinci ZhangThe First Hospital of Anhui University of Science and Technology, Huainan, 232000, Anhui Province, China. fy2022699@aust.edu.cn.

Funding

Clinical and Translational Research Project of Anhui Province 202304295107020036Clinical and Translational Research Project of Anhui Province 202427b10020071
6 · The paper itself

Abstract

purposeAdvanced mining technologies have increased the generation and exposure risk of coal dust nanoparticles (CD-NPs). While CD-NPs are known to cause lung damage, their effects on intestinal tissues following respiratory exposure remain unclear. Here, we investigated the damaging effects of CD-NPs on colonic tissues and the underlying mechanisms.

methodsRats were exposed to CD-NPs for 3, 6, and 9 weeks (n = 6 per group). Assessments included intestinal pathology, inflammatory status, barrier integrity, gut microbiota (16S rRNA sequencing), colonic transcriptomics (RNA-Seq), and cellular functional validation of ferroptosis pathways.

results: CD-NPs exposure caused significant colonic damage, elevated interleukin-6 / interleukin-17a levels, and reduced expression of tight junction proteins (Zonula occludens-1, Occludin, Claudin-1; all P < 0.05). The gut microbiota exhibited decreased alpha diversity, distinct beta separation, enriched pro-inflammatory taxa, and depleted anti-inflammatory commensals. Transcriptomics revealed downregulated oxidative phosphorylation and enriched ferroptosis (both P < 0.01). Functional experiments confirmed ferroptosis characteristics: reduced glutathione peroxidase 4, increased long-chain acyl-CoA synthetase 4, oxidative stress, mitochondrial dysfunction, Fe

conclusionRespiratory exposure to CD-NPs induces colitis-like lesions via gut microbiota dysbiosis and P53/SCO2/SLC7A11-mediated epithelial ferroptosis, impairing the intestinal barrier. These findings provide new insights into the health risks associated with coal dust exposure.

Indexed as

Amino Acid Transport System y+ColitisDysbiosisFerroptosisGastrointestinal MicrobiomeNanoparticlesTumor Suppressor Protein p53AnimalsColonDustIntestinal MucosaMaleRatsRats, Sprague-DawleyAmino Acid Transport System y+DustTp53 protein, ratTumor Suppressor Protein p53FerroptosisMitochondrial dysfunctionOxidative phosphorylationP53/SCO2/SLC7A11 pathway

Identifiers

PMID41925776
PMCPMC13500437

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