Evidence map›Paper›PMID 41925728›Full record

ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2026

Pediatric Emergency Department Care for Septic Shock in Sub-Saharan Africa: Single-Center Outcomes Before-Vs.-After Implementation of a Telesimulation Program, 2023-2024.

Vanessa C Denny, Justicia Amisah, John Adabie Appiah, Charlotte Z Woods-Hill, Heather A Wolfe, Gustav Nettey, Princess R Acheampong, Larko Owusu, Kyle Cassidy, Elizabeth Sanseau and 3 more

Abstract read
In one paragraph

Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vanessa C DennyDepartment of Anesthesiology, Critical Care and Pediatrics, University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0002-7651-0205
Justicia AmisahDepartment of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
John Adabie AppiahDepartment of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Charlotte Z Woods-HillDepartment of Anesthesiology, Critical Care and Pediatrics, University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Heather A WolfeDepartment of Anesthesiology, Critical Care and Pediatrics, University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Gustav NetteyDepartment of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Princess R AcheampongDepartment of Health Promotion and Education, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Larko OwusuDepartment of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Kyle CassidyAnnenberg Extended Reality Lab, Annenberg School for Communication, University of Pennsylvania, Philadelphia, PA.
Elizabeth SanseauDepartment of Anesthesiology, Critical Care and Pediatrics, University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Bingqing ZhangDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Data Science and Biostatistics Unit, Philadelphia, PA.
Ebor Jacob G JamesDepartment of Pediatrics, Christian Medical College, Pediatric Critical Care, Vellore, Tamil Nadu, India.
Vinay M NadkarniDepartment of Anesthesiology, Critical Care and Pediatrics, University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.

Funding

Leveraging implementation and behavioral science to reduce harmful overuse of diagnostic testing in critically ill childrenK23HL151381 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI WOODS-HILL, CHARLOTTE Z · 2021 to 2025
$890k
NHLBI NIH HHS K23 HL151381University of Pennsylvania Holman Africa Research and Engagement, CHOP Children's Anesthesia Associates Education Innovation, CHOP Center for Leadership and Innovation in Medical Education, CHOP Global Scientific Excellence AwardUniversity of Pennsylvania Holman Africa Research and Engagement, CHOP Children's Anesthesia Associates Education Innovation, HOP Center for Leadership and Innovation in Medical Education, CHOP Global Scientific Excellence Award
6 · The paper itself

Abstract

objectivesSepsis is a leading cause of preventable death in low-resource settings, where delays in recognition and emergency department (ED) treatment are common. Limited access to training also contributes to poor outcomes. We hypothesized that a contextualized telesimulation and debriefing program would be associated with better sepsis-related outcomes and time-critical care processes in children presenting to our center in Kumasi, Ghana. We also determined the program's acceptability and feasibility in our clinical providers.

designWe conducted a 12-month mixed-method quasi-experimental (before vs. after implementation) study at Komfo Anokye Teaching Hospital, 2023-2024. Pediatric ED providers completed 30-minute, low-bandwidth telesimulation sessions using culturally-adapted real patient videos, filmed in the local Ghanaian hospital. Clinical outcomes and care processes were evaluated pre- and post-intervention. Trained observers recorded time-critical interventions: shock recognition, oxygen use, IV access, fluid bolus, reassessment, blood cultures, and antibiotics. Acceptability and feasibility were assessed using validated surveys.

settingTertiary academic hospital with 1200 beds, including 15 pediatric ED beds and 4 PICU beds.

participantsED healthcare providers as well as clinical data from patients 2 months to 14 years old, screened at triage for suspected sepsis or septic shock.

interventionsNone. MEASUREMENTS AND MAIN

resultsPost- vs pre-implementation care periods had mortality of 7 of 67 (10%) vs. 25 of 70 (36%), which represents an associated decrease in odds ratio (OR) of death 0.2 (95% CI, 0.1-0.5; p = 0.001). The post- vs pre-implementation changes in care characteristics, included: greater odds of supplemental oxygen use (OR 2.4 [95% CI, 1.0-5.7] p = 0.044) and IV placement (OR 3.8 [95% CI, 1.3-13.1] p = 0.012). Also, among trainees, 44/45 agreed that the program was acceptable and feasible.

conclusionsIn our 2023-2024 pre- vs. post-implementation study, we found that contextualized telesimulation and debriefing were associated with lower odds of mortality, improved characteristics of care, and were acceptable and feasible to the healthcare team.

Indexed as

Emergency Service, HospitalShock, SepticAdolescentChildChild, PreschoolFeasibility StudiesFemaleGhanaHumansInfantMaleResource-Limited Settingscritical careglobal healthmortalitySepsisshocktelesimulation

Identifiers

PMID41925728
PMCPMC13317893

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.