ArticleJACC. Advances2026
Sex Differences in Age-Associated Concentric Remodeling and Diastolic Dysfunction.
Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Influence of sex and heart size on cardiovascular adaptations to 2 years of endurance exercise training in sedentary middle-aged adults.The Journal of physiology · 2026Article
- Advances in Women's Cardiovascular Health: Progress, Gaps, and the Road Ahead.JACC. Advances · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundDiastolic dysfunction is a fundamental substrate in heart failure with preserved ejection fraction, with its modulation by age, sex, and cardiovascular risk factors under active investigation.
objectivesThe purpose of this study was to determine the age onset of sex-related disparities in diastolic function to establish intrinsic sex differences in cardiac aging.
methodsWe analyzed key echocardiographic parameters related to left ventricular geometric remodeling and diastolic function in a large cohort (N = 42,077; females/males: 18,476/23,601) using covariate-adjusted general linear models. A sensitivity analysis was performed on a subgroup (N = 14,250) free of comorbidities.
resultsSignificant age-by-sex interactions were found for all key parameters with covariate adjustment (P < 0.001), indicating that age-associated differences diverged significantly between sexes. Females demonstrated increased age-related interventricular septal thickening, left ventricular end-diastolic diameter decline, and a marked rise in relative wall thickness after age 60 (interaction F = 18.88) indicating a shift toward concentric remodeling. Diastolic functional decline also exhibited a sex-dependent age-associated pattern: e' velocity decreased significantly and E/e' ratio increased significantly in females from the sixth decade (F = 26.32). Older females also exhibited larger left atrial volume index and higher tricuspid regurgitation pressure gradients. A composite z-score of these parameters revealed significant sex-specific disparities, pinpointing the sixth decade as the age of marked divergence in diastolic function (F = 36.86). These patterns persisted in the subanalysis of individuals without comorbidities.
conclusionsThe age-associated cardiac remodeling and reduced diastolic function in older females were independent of comorbidities, supporting intrinsic sex-specific differences in cardiac aging emerging after the menopausal transition. These findings support the development of precise, sex-specific prevention strategies.
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