Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2026
Sleep architecture and self-reported sleep quality are associated with Alzheimer's disease biomarkers in older adults without dementia.
Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03959202 (A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults
Who cites it
1 citing paper in PubMed.
- Insomnia symptoms and stress exposure interact in relation to Alzheimer's disease biomarkers.Journal of neurology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundSleep disruption is common in older adults and is a significant risk factor for developing Alzheimer's disease (AD). This study examines the association between self-reported sleep quality, actigraphy- and electroencephalogram (EEG)-measured sleep parameters, and plasma amyloid-tau-neurodegeneration (ATN) biomarkers in older adults without dementia.
methodsWe analyzed baseline data from a randomized controlled trial of 103 sedentary community-dwelling older adults with insomnia symptoms but without dementia. Participants completed the Pittsburgh Sleep Quality Index (PSQI) and wrist actigraphy, provided blood samples for plasma biomarker assays (amyloid-beta [Aβ] 42, Aβ40, Aβ42/40 ratio, total tau, and neurofilament light [NfL]), and a subsample (n = 56) underwent a 2-night ambulatory EEG. Multiple regression models tested associations between sleep measures and plasma ATN biomarkers.
resultsParticipants averaged 70.0 ± 6.0 years old, and 80.6% were female. Adjusted analyses showed greater rapid eye movement (REM) sleep percentage was associated with lower Aβ40 (β = -0.018; 95% confidence interval [CI] = -0.027, -0.010) and higher Aβ42/40 ratio (β = 0.016; 95% CI = 0.007, 0.025). Higher PSQI scores were nominally associated with higher Aβ42 (β = 0.017, 95% CI = 0.004, 0.031) and NfL (β = 0.034, 95% CI = 0.007, 0.062), but these associations did not sustain false discovery rate correction.
conclusionsGreater REM sleep was associated with a more favorable plasma amyloid profile, whereas associations between subjective sleep quality and plasma biomarkers were nominal and require confirmation in larger studies. These findings suggest that REM sleep architecture measured using ambulatory EEG may be particularly sensitive to amyloid-related changes prior to dementia. Clinical Trial Registration Number: NCT03959202.
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