Evidence map›Paper›PMID 41925143›Full record

ArticleACS nano2026

Predictive Screening of Ta

Ying Kong, Nicole J Machi, Fuze Jiang, Eszter J Barthazy Meier, Viktoria Agarwal, Zhou Dong, Sung Sik Lee, Jing Wang

Abstract read
In one paragraph

Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying KongInstitute of Environmental Engineering, ETH Zürich, 8093 Zürich, Switzerland.
Nicole J MachiScientific Center for Optical and Electron Microscopy (ScopeM), ETH Zürich, 8093 Zürich, Switzerland.
Fuze JiangDepartment of Information Technology and Electrical Engineering, ETH Zürich, 8092 Zürich, Switzerland.
Eszter J Barthazy MeierScientific Center for Optical and Electron Microscopy (ScopeM), ETH Zürich, 8093 Zürich, Switzerland.
Viktoria AgarwalInstitute of Environmental Engineering, ETH Zürich, 8093 Zürich, Switzerland.
Zhou DongDepartment of Health Sciences and Technology, ETH Zürich, 8092 Zürich, Switzerland.
Sung Sik LeeScientific Center for Optical and Electron Microscopy (ScopeM), ETH Zürich, 8093 Zürich, Switzerland.
Jing WangInstitute of Environmental Engineering, ETH Zürich, 8093 Zürich, Switzerland.ORCID 0000-0003-2078-137X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid development of two-dimensional (2D) MXenes has outpaced our understanding of their pulmonary safety, leaving a critical gap in clinical translation due to inconsistent data from traditional 2D cell cultures. Herein, we developed an immunocompetent three-dimensional (3D) alveolar model comprising A549 epithelial cells, MRC-5 fibroblasts, and THP-1-derived macrophages cultured at the air-liquid interface. This self-organized triculture forms a stratified epithelial-mesenchymal trophic unit with functional surfactant production and cell-cell crosstalk, providing a physiologically relevant platform for the predictive screening of potential nanomedicines. Following thorough characterization, we utilized this system to investigate the therapeutic potential of in-house synthesized Ta

Indexed as

LungModels, BiologicalTitaniumA549 CellsAdministration, InhalationHumansNitritesParticle SizeReactive Oxygen SpeciesSurface PropertiesTransition ElementsMXeneNitritesReactive Oxygen SpeciesTitaniumTransition Elements3D ALI lung modelantifibroticanti-inflammatoryantioxidantinhalable nanotherapeuticpredictive screeningTa4C3 MXene

Identifiers

PMID41925143
PMCPMC13085849

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.