ArticleHLA2026
Non-Classical HLA and MIC Risk Score Is Associated With Acute Kidney Transplant Rejection Beyond Classical HLA Matching.
Article in HLA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Matching of HLA-A, -B and -DRB1 is the gold standard in histocompatibility testing for kidney transplantation. A good HLA match reduces the risk of alloimmunisation, thereby decreasing the likelihood of graft failure and potentially enabling reduced immunosuppression therapy. However, the role of the non-classical HLA and MIC genes is not well established. We hypothesised that polymorphisms in these genes contribute additional risk of acute rejection after kidney transplantation, beyond what is explained by classical HLA mismatching. We developed and validated an oligogenic risk score based on ten polymorphisms in the HLA-E, -F, -G, MICA and MICB genes associated with time to acute rejection using Cox proportional hazards analysis in a single centre retrospective cohort of 1025 Finnish adult kidney transplant recipient-donor pairs. The score, particularly at the extreme ends, that is, the 1st and 10th deciles, was associated with rejection-free survival in both the discovery cohort (Cox multivariable model HR 1.20, 95% CI 1.08-1.33, p-value 4.350 × 10
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.