ArticleTransplant infectious disease : an official journal of the Transplantation Society
Multidrug-Resistant Gram-Negative Urinary Tract Infections (UTIs) Increase the Risk of Rejection, CMV Viremia, and Graft Loss After Kidney Transplantation.
Article in Transplant infectious disease : an official journal of the Transplantation Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Nitrofurantoin Susceptibility and the Landscape of Multidrug-Resistant Gram-Negative Uropathogens in Kidney Transplant Recipients During the First Post-Transplant Year.Antibiotics (Basel, Switzerland) · 2026Article
- When Colonization Is Not the Culprit: Multidrug-Resistant Gram-Negative Urinary Tract Infections as a Marker of Risk After Kidney Transplantation.Transplant infectious disease : an official journal of the Transplantation SocietyArticle
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14 authors.
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Abstract
backgroundMultidrug-resistant (MDR) Gram-negative UTIs caused by extended-spectrum β-lactamases (ESBL) and carbapenem-resistant Enterobacteriaceae (CRE) are increasingly common in kidney transplant recipients (KTR), yet their clinical consequences relative to other Gram-negative infections remain unclear.
methodsIn this single-center study from a high-endemic area, we retrospectively evaluated the impact of MDR colonization (Colonization), MDR Gram-negative infection (MDR Infection), presumptive MDR infection (i.e., no isolates available; Presump. MDR), and non-MDR Gram-negative infection (non-MDR Inf.) on major post-transplant complications, including CMV and BKPyV viremia, acute rejection, donor-specific antibodies (DSA), graft function, and overall transplant failure. We used multivariable cause-specific hazard Cox regression models with time-varying covariates and random-coefficient mixed models.
resultsAmong 521 KTRs, distributed across overlapping conditions, 212 (40.7%) had MDR Colonization, 92 (17.7%) MDR Infection, 61 (11.7%) Presump. MDR, 67 (12.9%) non-MDR Inf., and 242 (46.4%) had no infection. Compared with No Infection group, only MDR infection was associated with a steeper decline in eGFR slope (
conclusionDocumented MDR Gram-negative UTIs, but not colonization or non-MDR UTI, are independently associated with acute rejection, CMV viremia, and poorer kidney allograft outcomes.
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