ArticlePlant, cell & environment2026
Arabidopsis ECHIDNA Plays an Important Role in Auxin Regulation of Clathrin-Mediated Trafficking During Root Gravitropism.
Article in Plant, cell & environment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Arabidopsis ECHIDNA Plays an Important Role in Auxin Regulation of Clathrin-Mediated Trafficking During Root Gravitropism.Plant, cell & environment · 2026Article
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9 authors.
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Abstract
In plant cells, clathrin and its adaptor protein complexes at the plasma membrane (PM) and the trans-Golgi network/early endosome (TGN/EE) coordinate clathrin-mediated endocytosis and post-Golgi trafficking, processes that are essential for responses to diverse environmental cues. Previous studies show that the phytohormone auxin differentially regulates clathrin light and heavy chain (CLC and CHC, respectively) recruitment to establish the asymmetric distribution of the auxin efflux carrier PIN-FORMED2 (PIN2), thereby promoting root gravitropic responses. Our results showed that loss-of-function of the TGN/EE component protein ECHIDNA (ECH) in Arabidopsis resulted in defective root gravitropism and impaired PIN2 trafficking. We further found that membrane-associated clathrin and its adaptor protein complexes AP-1, AP-2 and the TPLATE complex were reduced at the PM and/or TGN/EE in ech mutants. Furthermore, loss of ECH function disrupted the trafficking of the auxin receptor TRANSMEMBRANE KINASE1, thereby preventing auxin-induced modulation of CLC and CHC membrane association during root gravitropism. Together, these findings suggest that ECH is essential for proper membrane localisation of clathrin and its adaptor complexes, highlighting its central role in clathrin-mediated trafficking and auxin-responsive regulation.
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