Evidence map›Paper›PMID 41924862›Full record

ArticlePaediatric and perinatal epidemiology2026

Perinatal Depression, Maternal Engagement and Child Social-Emotional Development: A Cohort Study.

Anna Larsen, John Kinuthia, Felix Abuna, Julia C Dettinger, Lauren Gomez, Mary Marwa, Nancy Ngumbau, Ben Odhiambo, Salphine Watoyi, Joshua Stern and 3 more

Abstract read
In one paragraph

Article in Paediatric and perinatal epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna LarsenDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-0096-9386
John KinuthiaDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Felix AbunaUniversity of Nairobi, Nairobi, Kenya.
Julia C DettingerSchool of Public Health, Department of Global Health, University of Washington, Seattle, Washington, USA.
Lauren GomezSchool of Public Health, Department of Global Health, University of Washington, Seattle, Washington, USA.
Mary MarwaUniversity of Nairobi, Nairobi, Kenya.
Nancy NgumbauDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Ben OdhiamboUniversity of Nairobi, Nairobi, Kenya.
Salphine WatoyiUniversity of Nairobi, Nairobi, Kenya.
Joshua SternSchool of Public Health, Department of Global Health, University of Washington, Seattle, Washington, USA.
Barbra A RichardsonSchool of Public Health, Department of Global Health, University of Washington, Seattle, Washington, USA.
Grace John-StewartSchool of Public Health, Department of Global Health, University of Washington, Seattle, Washington, USA.
Jillian PintyeSchool of Public Health, Department of Global Health, University of Washington, Seattle, Washington, USA.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Evaluating Infant PrEP Exposure During Pregnancy and BreastfeedingR01HD100201 · NICHD · UNIVERSITY OF WASHINGTON · PI PINTYE, JILLIAN · 2019 to 2023
$3.4M
Evaluating sexually transmitted infections among adolescent girls and young women within a pharmacy-based PrEP delivery model in Kenya.R01HD108041 · NICHD · UNIVERSITY OF WASHINGTON · PI BUKUSI, ELIZABETH ANNE, PINTYE, JILLIAN · 2021 to 2025
$3.3M
mWACh-PrEP: A SMS-based Support Intervention to Enhance PrEP Adherence during Pregnancy and BreastfeedingR01NR019220 · NINR · UNIVERSITY OF WASHINGTON · PI KINUTHIA, JOHN, PINTYE, JILLIAN · 2020 to 2024
$2.9M
Improving fathers' mental health, parenting, and familial engagement through an mHealth intervention in KenyaK01MH137324 · NIMH · UNIVERSITY OF WASHINGTON · PI Anna M Larsen · 2025 to 2026
$351k
Evaluating perinatal mood and anxiety disorder in Kenyan: a mixed methods approachF32HD108857 · NICHD · UNIVERSITY OF WASHINGTON · PI LARSEN, ANNA M · 2022 to 2023
$144k
Center for AIDS Research, University of Washington P30AI027757Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentMinistry of HealthNational Institute of Child Health and Human Development F32HD108857National Institute of Child Health and Human Development R01HD100201National Institute of Child Health and Human Development R01HD108041NIAID NIH HHS P30 AI027757NICHD NIH HHS F32 HD108857NICHD NIH HHS R01 HD100201NICHD NIH HHS R01 HD108041NIMH NIH HHS K01 MH137324NIMH NIH HHS K01MH137324-A1NINR NIH HHS R01 NR019220NINR NIH HHS R01NR019220
6 · The paper itself

Abstract

backgroundEvidence gaps remain regarding the influence of perinatal depression on mother-child engagement and child social-emotional development.

objectivesWe assessed relationships between perinatal depression, mother-child engagement and child social-emotional development among Kenyan mother-child pairs.

methodsMother-child pairs attending maternal-child health services in four sites in Western Kenya were followed from pregnancy through early childhood. Study nurses serially assessed perinatal depression (pregnancy, 6 weeks, and 9 months postpartum with the Center for Epidemiologic Studies Depression scale, CESD-10 scores ≥ 10), mother-child engagement activities (6-monthly, 24 to 60 months post-delivery with UNICEF Multiple Indicator Cluster Surveys) and child social-emotional delay (6-monthly, 30 to 60 months post-delivery with Ages and Stages Questionnaires). We estimated prevalence and correlates of low mother-child engagement and social-emotional delay.

resultsAmong 884 mothers, the median age was 26 years (IQR 22.0, 30.3), 91.6% were married, and 36.8% had perinatal depression. High mother-child engagement (≥ 4 activities in the prior 3 days) ranged from 27.1% to 94.1% from 24 to 60 months post-delivery. The frequency of child social-emotional delay ranged from 26.6% at 30 months to 4.4% at 60 months. Low mother-child engagement at any point (< 4 activities) was more common among women with perinatal depression (adjusted relative risk [RR] 1.20, 95% confidence interval [CI] 1.08, 1.33) and was associated with twice the risk of child social-emotional delay (RR 2.22, 95% CI 1.78, 2.77). Mothers who reported adverse childhood experiences (ACES) (RR 1.08, 95% CI 1.04, 1.11) and intimate partner violence (IPV) (RR 1.28, 95% CI 1.11, 1.47) interacted less frequently with their children than women without these experiences.

conclusionIn this cohort of Kenyan mother-child pairs followed from pregnancy through childhood, perinatal depressive symptoms were associated with lower mother-child engagement, which was associated with double the risk of child social-emotional delay.

Indexed as

Child DevelopmentDepressionDepression, PostpartumMother-Child RelationsMothersAdultChild, PreschoolFemaleHumansInfantKenyaMalePregnancyYoung Adultearly childhood developmentKenyamother–child engagementperinatal depressionsocial–emotional development

Identifiers

PMID41924862
PMCPMC13344516

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.