ReviewPoultry science2026
Pathological mechanisms of avian viral oncogenesis: The central role of MicroRNA.
Review in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Avian oncogenic viruses represent a major cause of neoplastic and immunosuppressive diseases in poultry, leading to substantial economic losses worldwide and providing valuable models for studying virus-induced tumorigenesis. Among these viruses, Marek's disease virus, avian leukosis virus, and reticuloendotheliosis virus induce lymphoid and hematopoietic malignancies through distinct yet convergent molecular mechanisms. Increasing evidence indicates that microRNAs and their viral homologs are central regulators linking viral infection to oncogenic transformation, immune dysregulation, and pathological outcomes. This review provides an integrated overview of microRNA's role in the pathogenesis and pathology of avian oncogenic viral diseases, emphasizing its contributions to lymphocyte proliferation, survival, immune modulation, and tumor development. We discuss the unique case of Marek's disease virus, in which a viral microRNA ortholog is indispensable for tumor induction in vivo, representing the first direct demonstration of a virus-encoded microRNA acting as a primary oncogenic factor in a natural host. In contrast, avian leukosis virus and reticuloendotheliosis virus exploit host microRNA pathways through insertional mutagenesis and NF-κB-mediated transcriptional activation, respectively, contributing to tumor progression in a context-dependent manner. The review further correlates molecular findings with gross and microscopic pathological lesions. It highlights how microRNA-driven regulatory networks shape disease severity, tissue tropism, and tumor morphology. So, these insights establish microRNA as a conserved molecular hub in avian viral oncogenesis and underscore its relevance for understanding viral tumor pathology, improving differential diagnosis, and advancing comparative oncology across species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.