Evidence map›Paper›PMID 41924746›Full record

SynthesisFrontiers in medicine2026

Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials.

Houriah Y Nukaly, Ibrahim R Halawani, H M Irtaza, Talah Alturkistani, Mohammed Rehab Serafi, Waseem Alhawsawi, Hassan Omar Bogari, Ferdous A Ahmed, Yara Alhaddad, Asem Shadid and 2 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Houriah Y NukalyDivision of Experimental Medicine, McGill University Health Centre, Montréal, QC, Canada.
Ibrahim R HalawaniFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
H M IrtazaDepartment of Medicine, Bahawal Victoria Hospital, Bahawalpur, Pakistan.
Talah AlturkistaniKing Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Mohammed Rehab SerafiFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Waseem AlhawsawiDepartment of Dermatology, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.
Hassan Omar BogariKing Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Ferdous A AhmedFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Yara AlhaddadBatterjee Medical College for Sciences and Technology, Jeddah, Saudi Arabia.
Asem ShadidDepartment of Dermatology, King Fahad Medical City, Riyadh, Saudi Arabia.
Ruaa AlharithySecurity Forces Hospital, Riyadh, Saudi Arabia.
Abdulhadi JfriCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Skin aging manifests as wrinkles, reduced elasticity, and roughness due to intrinsic and extrinsic factors. Peptide-based therapies enhance collagen synthesis and extracellular matrix integrity. This systematic review and meta-analysis (SRMA) evaluates the efficacy and safety of oral and topical peptides in improving hydration, elasticity, wrinkles, and brightness. Methods: A comprehensive search of MEDLINE, CENTRAL, and Web of Science was conducted following PRISMA guidelines. Randomized controlled trials (RCTs) assessing peptide effects on skin aging parameters were included. The Cochrane Risk of Bias Tool (RoB 2) assessed study quality. Data were synthesized using a random-effects model in RStudio (R version 4.1.1). Conclusion: Nineteen RCTs involving 1,341 participants were analyzed. Peptides, particularly oral formulations, significantly improved hydration and brightness, with a modest pooled effect on wrinkle reduction (MD = 0.27, Systematic review registration: identifier CRD420250652779.

Indexed as

collagen peptidesoral peptidesskin agingskin aging interventions treatmentstopical peptides

Identifiers

PMID41924746
PMCPMC13037056

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.