ReviewFrontiers in cardiovascular medicine2026
High-altitude thrombosis: divergent pathophysiological mechanisms and preventive strategies in acutely exposed population and native highlanders.
Review in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Synergistic Effects of Diabetes, Inflammatory/Coagulopathy Biomarkers, TG and Hypoxic Stress on Premature Coronary Heart Disease in High-Altitude Populations.Journal of cardiovascular development and disease · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose of review: High-altitude environments pose distinct physiological challenges, with marked differences in the thrombotic responses between high-altitude acutely exposed individuals (HAAEI) and long-term high-altitude natives (HAN). This narrative review explores the divergent mechanisms underlying thrombosis in these two populations, aiming to deepen understanding of hypoxia-induced vascular risk. Recent findings: Acute high-altitude exposure elicits a cascade of responses-including sympathetic overactivation, inflammation, polycythemia, increased blood viscosity, and endothelial dysfunction-that collectively heighten thrombosis risk. Central to this process is the hypoxia-mediated interaction of HIF with NF- Plain language summary: Hypoxia-induced alterations in inflammation and blood rheology play pivotal roles in high-altitude thrombosis. Population-specific prevention strategies are essential, and further research is needed to refine pathophysiological understanding and guide targeted interventions.
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