Evidence map›Paper›PMID 41924584›Full record

ArticleEye banking and corneal transplantation2026

Intraoperative Peripheral Iridotomy for Endothelial Keratoplasty with a 22-Gauge Needle.

Zainab Rustam, Anshuman Agrawal, Rhea Kulkarni, Fahd Mohamed, Jonathan Thomas, Joanne Choi, Christine Wang, Derick O Ansah, Phoenix Fan, Paloma R Mitra and 4 more

Abstract read
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Article in Eye banking and corneal transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Zainab RustamWilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Anshuman AgrawalWilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Rhea KulkarniKansas City University, Joplin, Missouri, USA.
Fahd MohamedCentral Michigan University College of Medicine, Saginaw, Michigan, USA.
Jonathan ThomasTexas A&M University, Bryan, Texas, USA.
Joanne ChoiWilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Christine WangWilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Derick O AnsahWilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Phoenix FanWilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Paloma R MitraWilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Krystal YearisWilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Fasika A WoretaWilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Divya SrikumaranWilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Allen O EghrariWilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.

Funding

NEI NIH HHS L30 EY024746
6 · The paper itself

Abstract

Purpose: To describe the approach and advantages of a 22-gauge (22G) needle for intraoperative peripheral iridotomy (PI) during endothelial keratoplasty. Methods: A superior approach is utilized to make an inferior PI. Intracameral lidocaine 1% and acetylcholine chloride 1% are injected intracamerally via a superior 1.1mm paracentesis incision for pain control and miosis. The 22G needle is bent near the hub with the bevel facing down. It is inserted through the paracentesis and passes through the pupil. As the needle-tip advances under the inferior iris, it is lifted periodically to identify its position until it reaches the ideal point for the PI. Counter-pressure is applied to the limbus at the exit point. The needle-tip is angled up and pushed through the iris and limbus so that the needle-shaft creates a standardized, patent, circular iridotomy (approximately 0.7mm diameter and 0.4mm Results: The median time to produce a PI using a 22G needle was 19 seconds (IQR: 14 to 24), compared to 85.5 seconds (IQR: 57 to 258) when using intraocular scissors (p<0.001, difference: 66.5 seconds, 95% CI: 33.5 to 238 seconds). Conclusion: A 22G needle offers a safe, affordable, and efficient method using a standardized size diameter to produce an inferior PI during endothelial keratoplasty. Additional studies would assist to identify an ideal needle size across global populations.

Indexed as

Descemet Membrane Endothelial KeratoplastyDMEKEndothelial KeratoplastyPeripheral IridotomyPupillary Block

Identifiers

PMID41924584
PMCPMC13038294

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.