Evidence map›Paper›PMID 41924569›Full record

ArticleChemical science2026

Electrochemically cooperative halogen-cation delivery enables modular electrophilic haloesterification of both activated and unactivated alkenes.

He-Huan Xu, Duo-Duo Qian, Yi Fan, Jia-Jia Zhang, Chang-Le Guo, Hai-Chao Xu

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Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

He-Huan XuHenan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang 53007 China hehuanxu@htu.edu.cn.ORCID https://orcid.org/0009-0002-7990-8662
Duo-Duo QianHenan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang 53007 China hehuanxu@htu.edu.cn.
Yi FanState Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University Xiamen 361005 China fanyi1019@xmu.edu.cn haichao.xu@xmu.edu.cn.
Jia-Jia ZhangHenan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang 53007 China hehuanxu@htu.edu.cn.
Chang-Le GuoHenan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang 53007 China hehuanxu@htu.edu.cn.
Hai-Chao XuState Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University Xiamen 361005 China fanyi1019@xmu.edu.cn haichao.xu@xmu.edu.cn.ORCID https://orcid.org/0000-0002-3008-5143

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intermolecular haloesterification of alkenes is a practical platform for modular ester synthesis. However, current methods are restricted to aryl-activated and directing-group-containing alkenes, leaving low-reactivity, electron-deficient alkenes with alkyl substituents largely underexplored. Notably, electrophilic reactions involving chloroesterification of electron-deficient alkenes are also challenging due to the difficulty in controlling selectivity. In this work, we present an electrochemically cooperative halogen-cation delivery strategy that achieves modular electrophilic haloesterification of both activated and unactivated alkenes with good chemo-, regio-, and diastereoselectivity levels. It exhibits enhanced reactivity (with yields of up to 90%) and selectivity (regioselectivities and diastereoselectivities exceeding 20 : 1), as the amide mediates the transfer of Cl

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PMID41924569
PMCPMC13036799

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