Trial reportDrug design, development and therapy2026
Induction with Ciprofol Decreases Propofol Requirement During Propofol-Remifentanil Total Intravenous Anesthesia Maintenance in Elderly Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Purpose: Elderly patients are susceptible to dose-dependent perioperative hypotension caused by propofol. This study investigates whether general anesthesia induction with ciprofol reduces subsequent propofol maintenance requirements and improves hemodynamic stability compared to propofol induction in elderly patients undergoing total knee arthroplasty (TKA). Participants and Methods: In this prospective, double-blind, randomized controlled trial, 52 elderly participants (≥ 65 years, ASA I-III) undergoing TKA were randomly allocated to receive propofol (2 mg/kg) or ciprofol (0.4 mg/kg) for anesthesia induction. All participants received standardized anesthesia protocol for maintenance. The primary outcome was the average propofol infusion rate. Secondary outcomes included intraoperative norepinephrine utilization, mean arterial pressure (MAP) fluctuations, time to extubation, and postoperative modified Aldrete scores. Data were analyzed using Results: The mean age was 70.62 ± 3.86 years in the ciprofol group and 69.08 ± 3.52 years in the propofol group with balanced sex distribution. During anesthesia maintenance, the ciprofol group required a significantly lower propofol infusion rate than the propofol group (2.70 ± 0.75 mg/kg/h vs. 4.18 ± 1.66 mg/kg/h; mean difference, -1.48 mg/kg/h; [95% confidence interval, -2.19 to -0.77], Conclusion: In relatively healthy elderly patients undergoing total knee arthroplasty, anesthesia induction with ciprofol is associated with reduced propofol maintenance requirements and decreased intraoperative norepinephrine utilization. Ciprofol may represent a promising alternative for anesthesia induction in this population, although further multicenter validation is warranted.
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