ArticleFrontiers in endocrinology2026
Associations of cholesterol, high-density lipoprotein and glucose index and triglyceride-glucose-related indices with carotid atherosclerosis in young and middle-aged individuals.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Correlation Between Fasting Blood Glucose and Serum Lipid Profile and Lipid Ratios in Patients with Type 2 Diabetes Mellitus in Southern Thailand: A Cross-Sectional Study.Medical sciences (Basel, Switzerland) · 2026Article
- Exploratory mediation analysis of body roundness index in the nonlinear association between CHG index and metabolic dysfunction-associated steatotic liver disease among non-diabetic adults.Frontiers in nutrition · 2026Article
- Association of the cholesterol-high-density lipoprotein-glucose index with coronary atherosclerotic burden in patients with coronary artery disease.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Associations of cholesterol, high-density lipoprotein, and glucose (CHG) index and triglyceride-glucose (TYG)-related indices are biomarkers of insulin resistance. However, the relationships between carotid atherosclerosis and the CHG index and TYG-related indices in young and middle-aged people are unclear. This cross-sectional study reported such associations in a general population. Methods: A total of 9,110 participants aged between 18 and 60 years were included. TYG index (ln(triglyceride (mg/dL) × blood glucose (mg/dL)/2), TYG-BMI index (TYG×BMI), TYG/HDL index (TYG/HDL cholesterol), and CHG index (ln[cholesterol (mg/dL) × blood glucose (mg/dL)/2 × HDL (mg/dL)) were calculated. The associations between carotid atherosclerosis and CHG- and TYG-related indices were analyzed via logistic regression analyses. Results: Carotid atherosclerosis was observed in 3,089 (33.9%) participants. CHG index was significantly associated with carotid atherosclerosis (odds ratio (OR): 2.47, 95% confidence interval (CI): 1.87-3.26; Q4 vs. Q1, OR: 1.79, 95% CI: 1.42-2.26). Similar associations were observed for the TYG index (OR: 1.26, 95% CI: CI: 1.08-1.48; Q4 vs. Q1, OR: OR: 1.32, 95% CI: 1.08-1.62), TY-BMI (OR: 1.01, 95% CI: 1.00-1.02; Q4 vs. Q1, OR: 1.55, 95% CI: 1.15-2.11) and TYG/HDL (OR: 1.10, 95% CI: 1.06-1.13; Q4 vs. Q1, OR: 1.60, 95% CI: 1.32-1.94). CHG had better performance than the TYG, TYGBMI, and TYGHDL in identifying carotid atherosclerosis (the area under the curve was 0.642 vs 0.599, 0.620, and 0.612, respectively). Conclusion: CHG index and TYG-related indices were associated with carotid atherosclerosis in young and middle-aged individuals. CHG had better performance than did TYG-related indices in identifying carotid atherosclerosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.