Evidence map›Paper›PMID 41924520›Full record

ArticleFrontiers in endocrinology2026

Comparative outcomes of day 4 versus day 5 embryo transfers by fertilization method.

Lin-Lin Tao, Bo Zheng, Guo-Zhen Li, Yasong Geng, Zhi-Wei Yang, Hao-Yang Dai, Jing Ma, Fang-Fang Dai

Abstract readComparative Study
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lin-Lin TaoReproductive Center, Xingtai Meihe Reproductive and Genetic Hospital, Xingtai, China.
Bo ZhengReproductive Center, Xingtai Meihe Reproductive and Genetic Hospital, Xingtai, China.
Guo-Zhen LiReproductive Center, Xingtai Meihe Reproductive and Genetic Hospital, Xingtai, China.
Yasong GengReproductive Center, Xingtai Meihe Reproductive and Genetic Hospital, Xingtai, China.
Zhi-Wei YangReproductive Center, Xingtai Meihe Reproductive and Genetic Hospital, Xingtai, China.
Hao-Yang DaiReproductive Center, Xingtai Meihe Reproductive and Genetic Hospital, Xingtai, China.
Jing MaHebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China.
Fang-Fang DaiReproductive Center, Xingtai Meihe Reproductive and Genetic Hospital, Xingtai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The aim of this retrospective cohort study was to evaluate the clinical and neonatal outcomes between day 4 and day 5 embryo transfer across different fertilization methods. Methods: This retrospective cohort study was conducted between January 2018 and March 2023, enrolling a total of 1,245 fresh embryo transfer cycles, including 1,023 Results: In IVF or ICSI cycles, no significant differences were found in clinical pregnancy rate (CPR), implantation rate (IR), live birth rate (LBR), or other clinical outcomes between transfers of day 4 and day 5 embryos ( Conclusion: In IVF or ICSI cycles, day 4 embryo transfer is considered a viable option or alternative to day 5 blastocyst transfer with no difference in clinical and neonatal outcomes. In IVF cycles with single high embryo transfer, day 4 transfer is recommended due to its significantly higher pregnancy rate compared to day 5 transfer. To reducing MPRs and preterm birth rates (PBRs), day 4 single embryo transfer is recommended if embryos achieve high-quality grade (full compaction) on day 4.

Indexed as

Embryo TransferFertilization in VitroSperm Injections, IntracytoplasmicAdultEmbryo ImplantationFemaleHumansPregnancyPregnancy OutcomePregnancy RateRetrospective StudiesTime Factorsclinical outcomesday 4 transferday 5 transferfertilization methodneonatal outcomes

Identifiers

PMID41924520
PMCPMC13036421

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.