ArticleFrontiers in microbiology2026
Genomic characterization and pathogenicity assessment of a novel strain of duck reovirus identified in China.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Isolation, identification, and pathogenicity of Novel Duck Reovirus strain from ducklings in China.Poultry science · 2026Article
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7 authors.
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Abstract
The global duck industry faces substantial challenges due to the emergence of novel duck reovirus (NDRV) infections, which are pathologically characterized by splenomegaly, hemorrhagic manifestations, and necrotic lesions in affected birds. Surviving ducklings often suffer from severe growth retardation. Here, we investigated an outbreak of hepatic necrosis in commercial ducklings from Shandong Province, China. After excluding other potential pathogens, an NDRV strain was isolated and designated SD416. This strain demonstrated infectivity in both chicken and duck embryos and induced syncytial formation in Vero cells. Full-genome sequencing revealed a 23,420-bp dsRNA genome consisting of 10 segments, displaying significant genetic divergence from other Chinese duck reovirus isolates. Phylogenetic analysis indicated that SD416 is genetically distinct from known DRV strains, particularly within the M2 and S3 genes. Furthermore, its σC protein-coding sequence exhibited notably high genetic variability compared to strains from other genotyping clusters. To evaluate the age-dependent pathogenicity of SD416, 1-, 7-, and 14-day-old ducklings were intramuscularly inoculated with 0.1 mL of allantoic fluid containing the virus at a titer of 1 × 10⁶ TCID₅₀/0.1 mL. The strain exhibited pronounced age-related virulence: 1-day-old ducklings developed severe hepatic and splenic lesions resulting in mortality, whereas ducklings inoculated at 7 and 14 days of age exhibited only splenic pathology and survived throughout the study. The SD416 strain was comprehensively characterized in terms of tissue tropism, pathogenesis, genomic structure, and evolutionary relationships. Our findings reveal a unique genomic and virulence pattern associated with this novel isolate, providing important insights into the biology of NDRV. These results underscore the need for enhanced surveillance and development of targeted intervention strategies to limit the spread of this virus in global waterfowl production systems.
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