ReviewInternational journal of nanomedicine2026
Biomimetic Nanoparticles for Bone Regeneration: Construction Strategies and Therapeutic Mechanisms.
Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone tissue is the hardest and most dynamic connective tissue in the human body, and its integrity is essential for maintaining both mechanical support and physiological functions. However, with the aging population, the incidence of fractures, osteoporosis, and bone defects has risen significantly, severely impairing patients' quality of life and creating a substantial social burden. Although autologous or allogeneic bone grafts and metallic or non-metallic implants can partially restore bone defects, their long-term efficacy is constrained by donor shortages, immune rejection, and limited regenerative capacity. Consequently, the development of efficient, precise, and biomimetic bone regeneration strategies is of great importance. In recent years, biomimetic nanoparticles have shown unique advantages in mimicking the bone microenvironment, delivering bioactive factors, and modulating cellular behavior due to their tunable structures and functions. This review summarizes the structural composition of bone tissue and its repair processes, highlights biomimetic nanoparticle construction strategies based on cell membranes, exosomes, proteins, and peptides, and discusses their roles in osteogenesis, mineralization, immune regulation, and neurovascular development. Finally, it explores their clinical translation prospects and associated challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.