ArticleCureus2026
Early Clinical Experience in the Management of Nodular Complications Following Cross-Linked Porcine Collagen Injection for Tear Trough Augmentation: A Two-Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Operational Standard for Tissue-Extracted Collagen Facial Injection Techniques.Clinical, cosmetic and investigational dermatology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cross-linked porcine collagen fillers have been utilized for tear trough augmentation, primarily for the correction of dark under-eye circles. However, when nodular complications occur, their management remains challenging due to the absence of predictable enzymatic degradation and the lack of standardized treatment protocols. Two patients developed non-inflammatory infraorbital nodules following tear trough augmentation with cross-linked porcine collagen filler. Ultrasound examination demonstrated well-defined hypoechoic lesions within the superficial subcutaneous plane. Both cases were treated with ultrasound-guided intralesional injection using sterile water for injection (SWFI) combined with lidocaine, with hyaluronidase added in one case, followed by local massage. Complete clinical and ultrasonographic resolution was observed within one day and one week, respectively. Based on these two cases, ultrasound-guided intralesional management using SWFI facilitates the mechanical dispersion of aggregated collagen filler and represents a safe, minimally invasive approach for treating nodular complications in the tear trough. Early ultrasound assessment enables accurate diagnosis and targeted intervention in this anatomically delicate region.
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Registered trials
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