Evidence map›Paper›PMID 41924400›Full record

ArticlebioRxiv : the preprint server for biology2026

Quantitative Imaging of the Heterogeneity of Brain Potassium Depletion in Experimental Focal Ischemia.

Alexander Kharlamov, Victor E Yushmanov, Kirk A Easley, Boris Yanovski, Stephen C Jones

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander KharlamovPreviously Department of Anesthesiology, Allegheny-Singer Research Institute, 320 E. North Ave., Pittsburgh, PA, 15212.
Victor E YushmanovPreviously Department of Anesthesiology, Allegheny-Singer Research Institute, 320 E. North Ave., Pittsburgh, PA, 15212.
Kirk A EasleyDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA, 30322, USA.
Boris YanovskiDepartment of Anesthesiology, B'nai Zion Medical Center, Sderot Eliyahu Golomb 47, Haifa, Israel.
Stephen C JonesCerebroScope, the dba entity of SciencePlusPlease LLC, 4165 Blair St., Pittsburgh, PA 15207-1508, USA.

Funding

MR DIFFUSION AND SPECTROSCOPIC IMAGING FOR ACUTE STROKER01NS030839 · NINDS · CLEVELAND CLINIC FOUNDATION · PI JONES, STEPHEN CARTER · 1994 to 2009
$2.6M
Noninvasive scalp detection of cortical spreading depression for brain injuryR43NS092181 · NINDS · SCIENCEPLUSPLEASE, LLC · PI JONES, STEPHEN CARTER · 2016 to 2018
$743k
Ischemic Edge Dynamics in Ischemic Stroke: Potassium and the Blood-Brain BarrierR21NS066292 · NINDS · ALLEGHENY-SINGER RESEARCH INSTITUTE · PI JONES, STEPHEN CARTER · 2009 to 2010
$416k
NINDS NIH HHS R01 NS030839NINDS NIH HHS R21 NS066292NINDS NIH HHS R43 NS092181
6 · The paper itself

Abstract

backgroundWith few exceptions, pathological progression in ischemic stroke is presumed to occur uniformly within the ischemic core region. These exceptions include edema formation, brain tissue [Na

methodsPermanent focal ischemia was produced in 13 rats for 2.5-5 h. Brain sections were quantitatively stained for K

resultsThe mean value of normal cortex [K

conclusionsWhile confirming previous results of quantitative losses of [K

Indexed as

acute focal ischemic strokebrainperi-infarct depolarizationspotassium imagingspreading depolarization

Identifiers

PMID41924400
PMCPMC13036601

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.