ArticleInternational journal of ophthalmology2026
3D choroidal vascularity index in hyperopic amblyopic eyes of preschool children: a case-control study using SS-OCTA.
Article in International journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimTo evaluate the three-dimensional choroidal vascularity index (3D-CVI) in amblyopic eyes of preschool children compared with age-matched healthy controls using swept-source optical coherence tomography angiography (SS-OCTA).
methodsA cross-sectional case-control study was conducted. Children aged between 4y and less than 7y diagnosed with hyperopic amblyopia were consecutively recruited between January 1, 2021 and May 30, 2024. Age-matched controls were selected from healthy children without ocular or systemic diseases. All participants underwent SS-OCTA scanning, and choroidal parameters-including 3D-CVI, choroidal vessel volume (CVV), and choroidal thickness (CT)-were analyzed in both foveal and parafoveal regions. Comparative and correlational analyses were conducted to examine differences between groups and to explore the relationship between best-corrected visual acuity (BCVA) and 3D-CVI.
resultsA total of 80 eyes (40 amblyopic and 40 age-matched controls) were included. 3D-CVI was significantly lower in the amblyopic group compared to controls in both the foveal [0.318 (0.2885-0.3525)
conclusionHyperopic amblyopic eyes in preschool children show significantly lower foveal and parafoveal 3D-CVI compared to normal controls, suggesting a potential reduction in 3D-CVI during early refractive development. Lower foveal 3D-CVI is also associated with poorer BCVA, suggesting that 3D-CVI may serve as a valuable parameter for monitoring structural changes in hyperopic amblyopia.
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