Evidence map›Paper›PMID 41924328›Full record

ArticleFrontiers in oral health2026

The impact of neoadjuvant immunochemotherapy on the prognosis of locally advanced oral carcinoma.

Yujie Ke, Zhicong Hong, Limei Guan, Xianyang Luo, Zhenhong Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yujie Ke *Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Zhicong Hong *Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Limei GuanDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Xianyang LuoDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Zhenhong YeDepartment of Reproductive Medicine, The Xiamen Maternity and Child Healthcare Hospital, School of Medicine, Xiamen University, Xiamen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to investigate the effect of preoperative neoadjuvant immunochemotherapy (NAICT) on the prognosis of patients with locally advanced oral squamous cell carcinomas (OSCC), thereby providing evidence-based guidance for the clinical management of OSCC. Methods: We conducted a retrospective cohort study of OSCC cases treated at our institution between 2017 and 2022. Kaplan-Meier survival curves, along with univariate and multivariate Cox regression analyses, were employed to identify independent factors influencing 3-year overall survival (OS) and disease-free survival (DFS) rates. Results: A total of 158 patients with locally advanced OSCC were included. 119 patients received simple surgical treatment, 15 patients underwent neoadjuvant chemotherapy (NAC) followed by surgery and 24 patients underwent NAICT followed by surgery. Multivariate analysis identified differentiation ( Conclusion: Compared to direct surgery or NAC followed by surgery, preoperative NAICT demonstrated a more favorable impact on the prognosis of patients with locally advanced OSCC, while exhibiting manageable treatment-related adverse effects.

Indexed as

disease-free survivalimmune checkpoint inhibitorsneoadjuvant immunochemotherapyoral squamous cell carcinomasoverall survival

Identifiers

PMID41924328
PMCPMC13036188

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.