Evidence map›Paper›PMID 41924298›Full record

ArticleJournal of the Endocrine Society2026

Free testosterone independently predicts metabolic syndrome severity in U.S. adolescent girls aged 12-19 years.

Christopher R McCartney, Aaron F Pannone, Su Hee Kim, Matthew J Gurka, Mark D DeBoer, Christine M Burt Solorzano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christopher R McCartneyDivision of Endocrinology and Metabolism, Department of Medicine, West Virginia University, Morgantown, WV 26506, USA.ORCID https://orcid.org/0000-0002-5421-4982
Aaron F PannoneDepartment of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID https://orcid.org/0000-0001-6035-2700
Su Hee KimAugusta Health Diabetes and Endocrinology Clinic, Fishersville, VA 22939, USA.ORCID https://orcid.org/0000-0003-2530-867X
Matthew J GurkaDepartment of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID https://orcid.org/0000-0002-3371-4582
Mark D DeBoerDivision of Endocrinology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID https://orcid.org/0000-0003-1462-591X
Christine M Burt SolorzanoDivision of Endocrinology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID https://orcid.org/0000-0002-5990-2995

Funding

ROLE OF ANDROGENS IN THE NEUROENDOCRINE DYSFUNCTION OF NASCENT PCOSR01HD102060 · NICHD · UNIVERSITY OF VIRGINIA · PI BURT SOLORZANO, CHRISTINE MICHELE · 2019 to 2023
$1.7M
Pathophysiology and therapeutic strategy for late reproductive aged women with PCOSK23HD098319 · NICHD · UNIVERSITY OF VIRGINIA · PI KIM, SU H. · 2019 to 2023
$708k
Metabolic Syndrome Severity in All of Us: Relationship with Social Determinants of Health and with Long-Term Risk for Cardiovascular DiseaseR03HL172130 · NHLBI · UNIVERSITY OF VIRGINIA · PI DEBOER, MARK DANIEL, GURKA, MATTHEW JAMES · 2023 to 2024
$323k
NHLBI NIH HHS R03 HL172130NICHD NIH HHS K23 HD098319NICHD NIH HHS R01 HD102060
6 · The paper itself

Abstract

Context: Hyperandrogenemia is associated with increased risks for metabolic syndrome in asymptomatic women and women with polycystic ovary syndrome. The relationship between hyperandrogenemia and metabolic syndrome in adolescent girls remains poorly defined. Objective: The aim of this study was to assess whether free testosterone concentrations predict metabolic syndrome severity (MSS) in adolescent girls. Design/setting: Using data from the U.S. National Health and Nutrition Examination Survey (2013-2016), we performed weighted regression analysis to evaluate whether free testosterone predicts MSS z-score after adjusting for body fat percentage, chronological age, and gynecological age. Similar analyses were performed using either total testosterone or sex hormone-binding globulin (SHBG) as the primary predictor variable. Participants: 287 girls aged 12-19 years. Main outcome measure: MSS z-score. Results: In simple regression analyses, free testosterone and percent body fat predicted MSS z-score ( Conclusion: Higher free testosterone predicts greater MSS in a nationally representative sample of adolescent girls aged 12-19 years. This relationship at least partly reflects the relationship between MSS z-score and SHBG.

Indexed as

adolescencehyperandrogenemiametabolic syndromeobesitysex hormone-binding globulintestosterone

Identifiers

PMID41924298
PMCPMC13035464

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.