ArticleClinical, cosmetic and investigational dermatology2026
Evaluation of the Effect of Laterality and Age on Pain Perception in Monopolar Radiofrequency Facial Therapy.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Monopolar radiofrequency (RF) is an established non-invasive modality for facial rejuvenation. Despite its proven efficacy, treatment-related pain remains a major barrier to patient compliance. Previous evidence suggests lateralized differences in pain perception, yet systematic evaluation in RF therapy is lacking. Purpose: To investigate laterality in pain perception during monopolar RF treatment and to explore the influence of age on pain sensitivity. Patients and Methods: A prospective study enrolled 46 patients (45 females, 1 male; age 30-58 years) with facial laxity undergoing bilateral monopolar RF (Thermage FLX) treatment. Treatment order (left-first or right-first) was randomized, and all procedures were performed by the same right-handed physician. Pain intensity was assessed within 5 minutes post-treatment for each hemiface using a 0-10 Visual Analogue Scale (VAS, scored to one decimal place). Results: The left hemiface exhibited significantly higher VAS scores than the right (7.12 ± 2.05 vs. 6.62 ± 1.90, Conclusion: Monopolar RF treatment demonstrates a consistent left-side dominance in pain perception, with younger patients exhibiting greater pain sensitivity and age negatively correlated with VAS scores.
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