Evidence map›Paper›PMID 41924266›Full record

ArticleFrontiers in immunology2026

Distribution of granzyme-expressing NK cells in tuberculosis reflects subset and compartment-specific remodeling.

Fuxiang Li, Youchao Dai, Shuixiang Xie, Rong Hu, Xueyun Gao, Xiao Huang, Shuxi Zhong, Yi Cai, Xinchun Chen, Junyun Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fuxiang LiDepartment of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Youchao DaiGuangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Shuixiang XieSchool of Basic Medicine, Gannan Medical University, Ganzhou, China.
Rong HuDepartment of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Xueyun GaoDepartment of Chemistry, Faculty of Environment and Life Science, Center of Excellence for Environmental Safety and Biological Effects, Beijing University of Technology, Beijing, China.
Xiao HuangThe First Clinical Medical College of Gannan Medical University, Ganzhou, China.
Shuxi ZhongThe First Clinical Medical College of Gannan Medical University, Ganzhou, China.
Yi CaiGuangdong Provincial Key Laboratory of Infection Immunity and Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen, China.
Xinchun ChenGuangdong Provincial Key Laboratory of Infection Immunity and Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen, China.
Junyun HuangDepartment of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Natural killer (NK) cells contribute to immunity against Methods: NK cell subsets and the expression of granzymes (GZMA, GZMB, and GZMK) and CCR5 were analyzed by multiparametric flow cytometry in peripheral blood from healthy controls, individuals with latent TB infection, active TB patients, and treated TB patients, as well as in paired pleural fluid samples. Results: In peripheral blood from active TB patients, NK cells exhibited reduced co-expression of GZMA, GZMB, and GZMK alongside decreased subset frequencies and absolute counts, a defect restored after treatment. In contrast, pleural fluid NK cells exhibited a distinct signature characterized by elevated GZMK but reduced GZMA and GZMB. This pattern was attributable to the relative enrichment of CD56 Discussion: These findings reveal granzyme remodeling and altered distribution of GZMK

Indexed as

GranzymesKiller Cells, NaturalLymphocyte SubsetsMycobacterium tuberculosisTuberculosisAdultCD56 AntigenFemaleHumansMaleMiddle AgedReceptors, CCR5Young AdultCCR5 protein, humanCD56 AntigenGranzymesGZMA protein, humanGZMB protein, humanReceptors, CCR5CCR5GZMAGZMBGZMKnatural killer cellstuberculosis

Identifiers

PMID41924266
PMCPMC13035492

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.