ArticleInfection and drug resistance2026
The Evolving Triad of Carbapenem Resistance: Emergence of Dominant CRPA, Persistent CRAB, and Rebounding CRKP in a Chinese Regional Hospital (2020-2024).
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Carbapenem-resistant Gram-negative bacteria (CR-GNB) represent a critical threat in healthcare settings. However, their evolving epidemiology in regional hospitals remains poorly understood. We aimed to delineate the resistance trends and risk factors of CR-GNB in a Chinese regional hospital to guide infection control. Patients and Methods: We conducted a retrospective epidemiological study from 2020 to 2024. A total of 148,622 clinical specimens were collected, yielding 19,264 culture-positive isolates. We examined microbial distribution and carbapenem resistance (CR) rates. Multivariable logistic regression was used to identify independent risk factors for CR-GNB infection. Results: The overall culture positivity rate was 12.96%. Gram-negative bacilli accounted for 71.7% of the positive isolates. CR analysis revealed a critical shift: Conclusion: Our findings reveal a critical shift in the CR-GNB landscape, characterized by the emergence of dominant CRPA alongside persistent CRAB and rebounding CRKP. This "Evolving Triad", entrenched in ICUs, underscores the urgent need for "Proactive Ecological Intervention" strategies. This study provides a crucial epidemiological baseline for regional hospitals.
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