ReviewFrontiers in cell and developmental biology2026
Redox regulation in aging muscles: exercise as a key modulator to combat sarcopenia and frailty.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Context: Aging is characterized by progressive decline in skeletal muscle function, which can lead to sarcopenia (loss of muscle mass and strength) and frailty (increased vulnerability to stressors), with oxidative stress-arising from an imbalance between reactive oxygen species (ROS) production and antioxidant defenses-playing a central role. This narrative review synthesizes evidence on how exercise modulates redox homeostasis to mitigate these conditions in older adults. Objectives: To explore the sources and consequences of oxidative stress in aging muscle, examine exercise's role in restoring redox balance, evaluate its impact on sarcopenia and frailty, and identify relevant biomarkers and future research directions. We achieve this by exploring key sources through representative studies, examining molecular mechanisms via pathway analyses, evaluating intervention effects using RCTs and meta-analyses, and identifying biomarkers and gaps through critical synthesis. Methods: This narrative review involved a comprehensive literature search in databases such as PubMed, Web of Science, and Scopus, focusing on studies from 2000 to 2025 on oxidative stress, exercise, sarcopenia, and frailty in adults aged 60+. Inclusion criteria prioritized peer-reviewed articles, meta-analyses, and RCTs; exclusion applied to non-English or irrelevant studies. Over 100 articles were selected qualitatively for synthesis. Key Findings: Aerobic and resistance exercises reduce oxidant markers (e.g., MDA decreased by 10%-20% in meta-analyses) and enhance antioxidants (e.g., SOD increased by 15%-30%), upregulating pathways like Nrf2, AMPK, and PGC-1α. Multicomponent programs improve muscle strength (e.g., 20%-40% gains in RCTs) and frailty scores (e.g., reductions in Fried Frailty Phenotype by 1-2 points). However, heterogeneous responses exist, with some studies showing neutral effects on certain markers. Conclusion: Exercise emerges as a non-pharmacological intervention to attenuate oxidative stress-driven muscle aging, promoting healthy aging. Future studies should focus on personalized regimens and long-term biomarkers for clinical translation.
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